ABSTRACT
Cervical-facial radiotherapy causes innumerable sequelae, being systemic or restricted to the oral environment. Theoral mucosa of these patients is profoundly compromised by radiotherapeutic treatment with or without chemotherapy,presenting several complications. Dentifrices containing sodium lauryl sulfate cause damage, as they lead to drynessof the mucosa. The objective of this work was to develop a dentifrice capable of minimizing xerostomia related toa lower abrasive effect, which was intended for hygiene, prevention of caries, control of dental biofilm, and toothsensitivity in cancer patients. The qualitative composition and physicochemical characteristics of ten dentifrices wereanalyzed, which enabled the preparation of the proposed formulation (PF) that was analyzed periodically for 180days. The quantitative analysis of spreadability not only indicated favorable behavior of the PF in relation to thepackaging and storage conditions but also revealed the need to raise the propylene glycol concentration in the PF toavoid the occurrence of syneresis after 60 days. Furthermore, pH data showed that the PF is compatible with the pHof oral homeostasis thus avoiding the occurrence of dental demineralization. It is suggested that the PF has a singularcomposition and physicochemical quality to be used as a suitable dentifrice for patients undergoing anticancer therapy