ABSTRACT
Background@#Resting-state functional connectivity (rs-FC) may aid in understanding the link between painmodulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. @*Methods@#This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (i.e., DPMS dysfunction, n = 13) or responders (n = 20) to CPM-test. A generalized linear model (GLM) and a receiver operating characteristic (ROC) curve analysis were performed to check the accuracy of the rs-FC to differentiate each group. @*Results@#Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (P < 0.001). The GLM analysis revealed that the S1-PAG rs-FC in the left-brain hemisphere was positively correlated with a central sensitization symptom and negatively correlated with sleep quality and pain scores. ROC curve analysis showed that left S1-PAG rs-FC offers a sensitivity and specificity of 85% or higher (area under the curve, 0.78, 95% confidence interval, 0.63–0.94) to discriminate who does/does not respond to the CPM-test. @*Conclusions@#These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.
ABSTRACT
O objetivo deste trabalho foi avaliar a influência de óleos vegetais no desenvolvimento corporal e composição do filé de jundiás. Foram testadas seis dietas (32 por centoPB), sendo avaliados óleos de arroz, canola ou soja com 5 ou 10 por cento de inclusão, durante 90 dias. Os peixes (180, peso inicial=71,0±0,8g) foram distribuídos ao acaso em 18 caixas (280L) de um sistema de recirculação de água, com temperatura controlada. Para avaliação de desempenho, estimaram-se variáveis como peso, comprimentos totais, padrão, altura caudal, sobrevivência, taxa de crescimento específico, fator de condição, consumo diário, conversão alimentar aparente e rendimento de partes comestíveis. Além disso, foram avaliadas a composição centesimal e taxas de deposição de proteína e gordura nos filés. Não houve diferenças entre os óleos e os níveis sobre o crescimento dos peixes; entretanto, os jundiás alimentados com 10 por cento de óleo depositaram mais gordura no filé. Conclui-se que os óleos de canola, arroz e soja proporcionam bom crescimento e rendimento de partes comestíveis. As dietas contendo óleo de canola, com 5 por cento de inclusão, possibilitam menor deposição de gordura no filé.
The influence of vegetable oils in the body development of jundiá (Rhamdia quelen) and its relationship with the flesh quality were evaluated in the present study. Six diets (32 percent of crude protein) with rice, canola or soybean oil at 5 or 10 percent of inclusion were tested, for 90 days. The fishes (180, initial weight=71± 0.8g) were randomly distributed in 18 boxes (280L) in a water re-use system, with controlled temperature. The following parameters were considered for evaluation of fish performance: weight, total and standard length, survival, specific growth rate, condition factor, daily consumption, food conversion ratio, carcass and fillet yield, proximate composition and protein and fat deposition in the filets. There were no differences for the productive parameters among the tested treatments. Fishes fed with higher oil levels in the diets deposited larger fat percentage in the fillet. Canola, rice and soybean oils used as alternatives in diets in rearing of jundiá (Rhamdia quelen) provide good growth and carcass and fillet yield. Diets containing 5 percent of canola oil lead to a small fat deposition in the fillet of jundiás juveniles.