Correlation between Ile50Val polymorphism of IL-4 receptor gene and susceptibility to asthma / 中国实用内科杂志

Objective To investigate correlation between Ile50Val polymorphism of IL-4 receptor gene and asthma and the impact on plasm total IgE,sIL-4R level.Methods the DNA is isolated from 2ml venous blood from 100 nomal subject and 100 asthma subject.The genetic polymorphism was identified by Allele-specific PCR techniquers,plasm total IgE,sIL-4R level was determined by ELISA.Results The frequency of genetype is significantly different be- tween control group and asthma group x~2=18.94,P