ABSTRACT
Progressive multifocal leukoencephalopathy [PML] is a rare demyelinating disease caused by reactivation of a latent JC polyoma virus. The first cases of PML were described 50 years ago in patients with lymphoma. PML typically occurs in immunocompromised individuals, particularly those infected with HIV. We present a 52-year-old male with lymphoma who was treated with R-CHOP [R: Rituximab; C: Cyclophosphamide; H: Doxorubicin; O: Vincristine; P: Prednisone]. After six cycles of therapy, the patients developed tonic-clonic seizure. MRI of the brain showed multiple brain lesions. The pathology of a brain biopsy was diagnostic for PML. We review radiographic and histopathological features of the disease. The literature on PML and its association with immunosuppressant agents is reviewed, and the impact of rituximab and other biological agents in the setting is highlighted
ABSTRACT
We report a 47-year-old male patient who developed acute kidney injury requiring hemodialysis, associated with massive enlargement of both kidneys. A part from intra-abdominal lymphadenopathy, there was no other organ or lymph node involvement. A kidney biopsy established the diagnosis of non-Hodgkin's lymphoma. The patient received chemotherapy with good response. This case demonstrates that the kidney could be the primary organ involved in non-Hodgkin's lymphoma. In addition, we have shown that renal biopsy is adequate to make a diagnosis of lymphoma without the need to do more invasive testing