ABSTRACT
Background: obesity is one of the most important health problems in many countries which increase the incidence of cardiovascular diseases. Although cardiovascular findings are specific to adulthood, but identification of cardiovascular risk factors in childhood is necessary to prevent damage to target organs in adulthood The aim of this study was to evaluate the frequency of cardiovascular risk factors in obese children and adolescents
Methods: this cross-sectional descriptive study was performed on 442 children and adolescents aged 4 to 16 years old. After the clinical examination, blood pressure, height and weight were measured. The body mass index over than 95th percentile for age and sex or BMI Z-Score equal or more than 2] was defined as obesity. After 12 hours of fasting, the blood samples were taken for measurement of serum lipid profiles, insulin and glucose levels
Results: of the total obese subjects, 15.8% [n=70] had no risk factors for cardiovascular disease, while 22.2% had one, 32.4% had two, 22.4% had three, 2.5% had four and 1.6% had five risk factors. The most common risk factor was hypertriglyceridemia [52.3 %] and the second risk factor was impaired fasting blood glucose [34.9%]
Conclusion: the prevalence of cardiovascular risk factors is high in obese children and adolescents
ABSTRACT
Background: Helicobacter pylori infection is one of the most common chronic bacterial infections
There is challenge on the real rate of prevalence of H. pylori in diabetic patients
This study was done to assess the prevalence of H. pylori infection in children suffering from type 1 insulin-dependent diabetes mellitus
Methods: In this case-control study, 80 diabetic patients [as the target group] refer to the Endocrinology Clinic of Tabriz Educational and Treatment Center, Tabriz northwestern Iran and 80 non-diabetic patients [as the control group] from the group of children referring to the Gl Clinic of the same center were enrolled in 2012 and 2013. Then H. pylori infection was assessed in two groups using measuring antibody [IgG] and stool antigen [HpSA]
Results: H. pylori infection tests were positive in 48 [60%] diabetic patients and in 32 [40%] in non-diabetic patients [P=0.030]
There was a meaningful correlation between the frequency of H. pylori and the longer the duration of diabetes [P<0.001]. No correlation was seen between H. pylori infection and other factors such as age of the patients [P=0.840], HbA1C level [P=0.312], age at which diabetes was diagnosed [P=0.800], average daily dosage of insulin [P=0.232], and presence of Gl symptoms [P=0.430]
Conclusions: Type 1 diabetic children especially cases with the longer duration of diabetes, are at risk acquiring H. pylori infection
Therefore, screening of H. pylori infection is helpful on the follow up of these patients
ABSTRACT
Eosinophilic gastroenteritis [EGE] was a rare gastrointestinal disease that was seen in all ages usually associated with dyspepsia, diarrhea, vomiting, abdominal pain, blood loss in stools and malabsorption. We reported a six-month-old boy with rectorrhagia, family history of allergy, elevated IgE and eosinophil in blood with normal endoscopy. Because of eosinophilic infiltration in lamina properia in colon, diagnosis of EGE confirmed and oral corticosteroid initiated. Patient had symptomatic response and was doing well. The heterogeneity in the clinical presentation of EGE determined by the site and depth of eosinophilic intestinal infiltration and lower gastrointestinal bleeding, although was rare but may be one the clinical manifestations of disease in patients with allergic eosinophilic gastroenteritis [AEG]
ABSTRACT
Approximately 20-50% of childhood cancer survivors will develop at least one endocrine disorder in their life time. The purpose of this study was to evaluate endocrine disorders caused by the disease or complications of treatment among cancer survivors. This cross sectional study was conducted on 72 survivors of childhood cancer patients with the age of 2-18 years, who were followed up in Pediatric Oncology Clinic of Tabriz children's hospital from September 2001 to March 2012. Age, gender, type and site of malignancy and prescribed medications were recorded. After clinical examination, Blood samples were taken and sent to the reference laboratory to measure serum levels of fasting blood sugar, calcium, phosphorus, thyroid and gonadal function tests. The mean age of patients at their diagnosis time and after treatment were 11.43 +/- 3.39 and 3.2 +/- 1.34 years, respectively. 77.8% were male and 22.2% female. Acute lymphoblastic leukemia was the most common malignancy [55.5%]. 88.9% of patients had received vincristine. 27.7% of survivors had at least one endocrine complication. Impaired fasting glucose, hypothyroidism, hypogonadism were 16.7%, 8.3% and 2.7%, respectively. Survivors of childhood malignancy are at risk of endocrine complications, especially impaired glucose metabolism, thyroid and gonadal dysfunction. The diagnosis and treatment of these disorders in vulnerable individuals can reduce mortality and improve their quality of life