ABSTRACT
To determine the sequence variant of TLL1 gene [rs1503298, T > C] in three British cohorts [PREDICT, UDACS and ED] of patients with type-2 Diabetes mellitus [T2DM] in order to assess its association with coronary heart disease [CHD]. Analytical study. UCL, London, UK. Participants were genotyped in 2011-2012 for TLL1 SNP. Samples and related information were previously collected in 2001-2003 for PREDICT, and in 2001-2002 for UDACS and ED groups. Patients included in PREDICT [n=600], UDACS [n=1020] and ED [n=1240] had Diabetes. TLL1 SNP [rs1503298, T > C] was genotyped using TaqMan technology. Allele frequencies were compared using c2 test, and tested for Hardy-Weinberg equilibrium. The risk of disease was assessed from Odds ratios [OR] with 95% Confidence Intervals [95% CI]. Moreover, for the PREDICT cohort, the SNP association was tested with Coronary Artery Calcification [CAC] scores. No significant association was found for this SNP with CHD or CAC scores in these cohorts. This SNP could not be confirmed as a risk factor for CHD in T2DM patients. However, the low power of thesmall sample size available is a limitation to the modest effect on risk. Further studies in larger samples would be useful