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1.
Int. j. morphol ; 31(1): 345-350, mar. 2013. ilus
Article in English | LILACS | ID: lil-676178

ABSTRACT

The aim of this study was to accurately measure acromial morphology in order to describe the anatomical patterns of its subtypes and to conduct a survey of the literature regarding the relationships between morphological subtypes and their related diseases. We photographed scapulae from the Institute of Anatomy, University Severino Sombra, and analyzed the images using Image-J Software®. The average acromial angle was 139.23° ± 2.781, with no significant difference between the right and left sides. There was a positive correlation between the acromial angle and the angle of the spine of the scapula. The correlation mentioned above plays an important role in disorders of the shoulder-particularly impingement syndrome-which reinforces the importance of acromial morphology studies.


El objetivo de este estudio fue medir con precisión la morfología acromial para describir los patrones anatómicos de sus subtipos y llevar a cabo un estudio de la literatura sobre las relaciones entre los subtipos morfológicos y las enfermedades relacionadas. Tomamos fotografías de la escápula del Instituto de Anatomía de la Universidad Sombra Severino, y se analizaron las imágenes con el Software Image-J®. El ángulo acromial medio fue de 139,23 ± 2,781°, no habiendo diferencias significativas entre los lados derecho e izquierdo. De observó una correlación positiva entre el ángulo acromial y el ángulo de la columna vertebral de la escápula. La correlación mencionada anteriormente, juega un papel importante en los trastornos de la inflamación del hombro, especialmente el síndrome, lo cual refuerza la importancia de los estudios de la morfología acromial.


Subject(s)
Humans , Acromion/diagnostic imaging , Software , Acromioclavicular Joint , Acromion/anatomy & histology , Cadaver , Prospective Studies
2.
J. vasc. bras ; 11(3): 175-181, jul.-set. 2012. ilus, graf
Article in Portuguese | LILACS | ID: lil-653555

ABSTRACT

CONTEXTO: A terapia a laser de baixa intensidade (LLLT) tem sido relatada como importante moduladora da cicatrização de feridas cutâneas aumentando a proliferação fibroblástica associada ao aumento da expressão da citocina fator transformador de crescimento- β2 (TGF-βB2). OBJETIVO: No presente estudo foram avaliados os efeitos da LLLT sobre a expressão da enzima ciclooxigenase 2 (COX2) no sítio do reparo tecidual utilizando o modelo experimental com camundongos diabéticos não obesos (NOD) para estudar a cicatrização de feridas cutâneas. MÉTODOS: Foram utilizados 30 camundongos NOD, destes 14 ficaram diabéticos e foram divididos em dois grupos: o grupo I (n=7) foi submetido a um procedimento cirúrgico de feridas cutâneas e o grupo II (n=7) foi submetido a um procedimento cirúrgico de feridas cutâneas e tratados com LLLT. O grupo II foi submetido à LLLT nos seguintes parâmetros: 15 mW de potência, dose de 3,8 J/cm² e tempo de aplicação de 20 segundos. Após sete dias do ato cirúrgico e após aplicação do laser, os animais foram eutanasiados com sobredose de anestesia e amostras das feridas foram colhidas para posterior análise histopatológica, histomorfométrica e imuno-histoquímica. RESULTADOS: A LLLT promoveu a inibição da expressão da COX2 em feridas cutâneas de camundongos diabéticos. CONCLUSÃO: Em conjunto, os resultados sugeriram que a LLLT é capaz de modular negativamente a expressão da enzima COX2 contribuindo para o controle da resposta inflamatória em feridas cutâneas de camundongos NOD.


BACKGROUND: Low-level laser therapy (LLLT) has been reported to modulate the healing of wounds by inducing an increase in fibroblast number associated with increased expression of the cytokine transforming growth factor-β2 (TGF-β2). OBJECTIVE: In the present study, the effect of LLLT on expression of COX2 at the site of tissue repair was evaluated, using an experimental model with non obese diabetic mice (NOD) to study cutaneous wound healing. METHODS: Thirty NOD mice were used, of which 14 were diabetic and were divided into two groups: group I (n=7) underwent a surgical procedure of skin wounds and group II (n=7) underwent a surgical procedure of skin wounds and treated with LLLT. Group II was submitted to LLLT in the following parameters: 15 mW of power, dose of 3.8 J/cm² and exposure time of 20 seconds. Seven days after surgery and after laser application, animals were euthanized with an overdose of anesthesia and tissue samples were collected for subsequent histological analysis, histomorphometry and immunohistochemistry. RESULTS: The LLLT has promoted the inhibition of COX2 expression in skin wounds in mice diabetic. Taken together the results suggest that LLLT modulate the expression of COX2 improved the control of inflammatory reaction in cutaneous wound lesions in NOD mice. CONCLUSION: Taken together, the results suggested that LLLT is able to negatively modulate the expression of COX2 enzyme contributing to the inflammatory response in cutaneous wounds in NOD mice.


Subject(s)
Animals , Mice , Diabetes Mellitus, Experimental/blood , Low-Level Light Therapy , Mice, Inbred NOD , Nitric Oxide/adverse effects , Animal Experimentation/ethics , Wounds and Injuries/veterinary , Blood Glucose/analysis
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