ABSTRACT
ABSTRACT Objective: Based on hypothetical hypothyroidism and nonthyroidal illness syndrome (NTIS) gene expression similarities, we decided to compare the patterns of expression of both as models of NTIS. The concordant profile between them may enlighten new biomarkers for NTIS challenging scenarios. Materials and methods: We used Ion Proton System next-generation sequencing to build the hypothyroidism transcriptome. We selected two databanks in GEO2 platform datasets to find the differentially expressed genes (DEGs) in adults and children with sepsis. The ROC curve was constructed to calculate the area under the curve (AUC). The AUC, chi-square, sensitivity, specificity, accuracy, kappa and likelihood were calculated. We performed Cox regression and Kaplan-Meier analyses for the survival analysis. Results: Concerning hypothyroidism DEGs, 70.42% were shared with sepsis survivors and 61.94% with sepsis nonsurvivors. Some of them were mitochondrial gene types (mitGenes), and 95 and 88 were related to sepsis survivors and nonsurvivors, respectively. BLOC1S1, ROMO1, SLIRP and TIMM8B mitGenes showed the capability to distinguish sepsis survivors and nonsurvivors. Conclusion: We matched our hypothyroidism DEGs with those in adults and children with sepsis. Additionally, we observed different patterns of hypothyroid-related genes among sepsis survivors and nonsurvivors. Finally, we demonstrated that ROMO1, SLIRP and TIMM8B could be predictive biomarkers in children's sepsis.
ABSTRACT
Observation about conhabitation among B. glabrata and B. tenagophila revealed a greater vulnerability of B. tenagophila population during the process of competition when its density was severaly decreased in 12 trials, moderate in 2 trials. It was higher than B. glabrata in only one trial. Some snail water chemical parameters analysed such as pH, alkalinity, conductivity and oxygen dissolve, an the viability rate of batch of eggs didn't give subsidy to explain the competition mechanism. The newly-born survival, in the situation of cohabitation, was low for both species. This reveals the existence of intra and interspecific competitive interacition. The fertility rate reduction of B. tenagophila during the cohabitation was considered as a cause of its exlusion. One of the factors that seems to have influenced the fertility rate was a possible wrong crossing.
Subject(s)
Animals , Biomphalaria , Candida glabrata , Research DesignABSTRACT
A DRT-MG, atuando como órgäo de prevençäo primária na área de doenças profissionais, realizou, por meio de médicos de trabalho, levantamento em 79 indústrias de reforma ou fabricaçäo de acumuladores elétricos na Grande Belo Horizonte. Ficou evidenciado nesse trabalho a quase total desinformaçäo sobre a intoxicaçäo profissional pelo chumbo e também sobre quaisquer métodos prevencionistas, havendo sido constatados ambientes de trabalho em péssimas condiçöes de higiene industrial e a total ausência de controle médico da saúde do trabalhador exposto ao agente. Foi constatada, através de avaliaçäo clínica e laboratorial, intoxicaçäo profissional por chumbo em 51,9% dos empregados avaliados, deixando patente a urgente necessidade de modificaçöes para controle ambiental e de uma conscientizaçäo efetiva dos indivíduos envolvidos nessa atividade
Subject(s)
Adult , Middle Aged , Humans , Occupational Diseases , Lead Poisoning , Metallurgy , BrazilABSTRACT
A DRT-MG, atuando como órgäo de prevençäo primária na área de doenças profissionais, realizou, através de médicos do trabalho, levantamento em 79 indústrias de reforma ou fabricaçäo de acumuladores elétricos na Grande Belo Horizonte. Ficou evidenciado nesse trabalho a quase total desinformaçäo sobre a intoxicaçäo profissional pelo chumbo e também sobre quaisquer métodos prevencionistas, havendo sido constatados ambientes de trabalho em péssimas condiçöes de higiene industrial e a total ausência de controle médico da saúde do trabalhador exposto ao agente. Foi constatada, através de avaliaçäo clínica e laboratorial, a intoxicaçäo profissional pelo chumbo em 51,9% dos empregados avaliados, deixando patente a urgente necessidade de modificaçöes para controle ambiental e de uma conscientizaçäo efetiva dos indivíduos envolvidos nessa atividade