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1.
Medicina (B.Aires) ; 55(5/1): 391-6, 1995. tab, graf
Article in Spanish | LILACS | ID: lil-161614

ABSTRACT

The usefulness of different techniques to measure platelet bound IgG has been reviewed by George(16). We present here the results obtained with a technique designed to measure membrane bound IgG employing an anti-human IgG labeled with peroxidase and using O-dianisidine-H2O2 to reveal the enzymatic activity(17). We studied 152 patients with chronic autoimmune thrombocytopenic (ATP) including 120 adults and 32 children (age below 15 years old), diagnosed by exclusion of diseases that may be associated with thrombocytopenic purpura of either immune or non-immune mechanisms. Besides, 79 patients with thrombocytopenia related to other diseases were also evaluated. The normal values in 215 controls were 188 +/- 4 IgG molec/platelet (mean +/- SE), while in the whole population of chronic ATP the results were 4714 +/- 344, p < 0.001. In pediatric cases the results had a tendency to values higher than in adults. A negative correlation was found between the number of platelets and the amount of bound IgG, r = 0.41 p < 0.001. IgG bound platelets were also increased in treated patients at relapse. The percent of normal IgG bound platelet was 4,5 percent in patients with a platelet count below 50.000/microliter and 39 percent in those with normal platelet number. Patients with secondary thrombocytopenia had elevated IgG/platelet while the values were normal in patients with thrombocytopenia of unknown etiology. We conclude that the immunoperoxidase technique is useful to establish the immunologic nature of thrombocytopenia.


Subject(s)
Humans , Male , Female , Child , Pregnancy , Immunoenzyme Techniques , Immunoglobulin G/blood , Purpura, Thrombocytopenic, Idiopathic/immunology , Age Factors , Autoimmune Diseases/complications , Chronic Disease , Platelet Count , Purpura, Thrombocytopenic, Idiopathic/complications , Receptors, Antigen, B-Cell , Thrombocytopenia/complications , Thrombocytopenia/immunology
2.
Colomb. med ; 17(2): 85-90, 1986. ilus, tab
Article in Spanish | LILACS | ID: lil-81494

ABSTRACT

Mediante un estudio estaditico en 200 individuos colombianos se determino la frecuencia con que se presentaron los 3 morfotipos digitales del antepie, egipcio, cuadrado y griego. Se encontro un predominio del antepie cuadrado, 56.3%; seguido del egipcio, 31.5%; y en tercer lugar el griego, 11.8%. Esta distribucion se mantuvo para ambos sexos y fue independiente de la edad y la altura del municipio de nacimiento de los individuos. La distribucion por razas indico un predominio del antepie cuadrado en la raza blanca (56.7%) y del antepie egipcio en la raza negra (47.5%). Se determino tambien la frecuencia con que se presentaban en estos individuos las modalidades en asa, en rizo y en arco o halux y su relacion con los morfotipos digitales del antepie. El dermatoglifo mas frecuente fue el asa, 61.5%; seguido por el arco, 19.6%. Las asociaciones mas frecuentes fueron las de asa con el antepie cuadrado, 30.4%; y con el antepie egipcio, 21.3%; seguidas por las asociaciones entre arco y antepie cuadrado, 9.5%; asa y antepie griego, 9.3%; arco y antepie egipcio, 7.5%. La deformidad en halux valgo o desviacion lateral del primer dedo solo se presento en 1.5% de estos individuos, con predominio en el sexo femenino (1.9%) y en los individuos mayores de 70 anos (3.9%). La prevalencia del halux valgo en el antepie cuadrado fue 60.1%; en el antepie griego, 30.3% y en el egipcio, 3.3%


Subject(s)
Humans , Fingers , Foot , Colombia
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