ABSTRACT
To determine if propofol-MCT/LCT premixed with lignocaine as well as given alone is effective in reducing pain on injection. Three hundred American Society of Anesthesiologists I-II patients listed for different elective procedures were randomized to three groups of 100 patients each. Group A received Diprivan a long-chain triglyceride preparation [LCT-propofol] premixed with lignocaine [i.e., 2 ml of 1% lignocaine in 20 ml of propofol]. Group B received Propofol-Lipuro [MCT/LCT-propofol] premixed with 2 ml normal saline, and group C received Propofol-Lipuro [MCT/LCT-propofol] premixed with lignocaine [2 ml of 1% lignocaine in 20 ml of propofol]. Anaesthesia was standardized in all the three groups. Undiluted Diprivan [LCT-propofol] and Propofol-Lipuro [MCT/LCT-propofol] were used for induction of anaesthesia and subjects were questioned about discomfort until contact was lost. Discomfort was recorded as none, mild, moderate or severe. Frequency of pain was 26% in group A [16% mild, 06% moderate and 04% severe pain,]. In group B frequency of pain was 28% [22% mild, 06% moderate and none severe pain], and in group C only 05% patients felt mild pain. None of them had moderate or severe pain. The p-value was 0.000007 in group C Vs A, 0.000027 in group C Vs B and 0.436782 in group B Vs A. The addition of lignocaine to MCT/LCT propofol significantly reduced the incidence of pain on injection compared to LCT-propofol with lignocaine p-value 0.000027 and MCT/LCT-propofol alone. Propofol MCT/LCT alone does not provide any advantage to reduce pain on injection in comparison to propofol MCT/LCT premixed with lignocaine