Progress on brain-targeting non-viral gene delivery systems / 国际药学研究杂志

Brain-targeting non-viral gene delivery systems could efficiently mediate gene drugs to cross blood-brain barrier and reach the diseased regions. Many researches have demonstrated that enhanced brain accumulation and gene expression could be achieved via appropriate mechanisms such as specific ligand-receptor binding function. In this review, progress on brain-targeting non-viral gene delivery systems mainly based on receptor- and adsorptive-mediated mechanisms is reviewed.