Comparison of survival periods and response in three modes of treatment for Cancer esophagus at CENAR Quetta

Esophageal cancer is a fatal disease, with mortality matching the incidence. Balochistan province and Afghanistan happen to fall in the "Esophageal Cancer Belt". This study was designed to compare survival periods and response in three different modes of treatment for cancer of esophagus at CENAR Quetta i.e Radiotherapy Plus Surgery, Radiotherapy plus Surgery plus single agent chemotherapy and Radiotherapy plus Surgery plus combined chemotherapy. During 1997, 59 patients with histopathological evidence of Ca esophagus were referred to CENAR from primary health care centers in Balochistan and Afghanistan. These 59 patients were divided into three groups. Group:I [n=22] treated by local irradiation plus surgery. Group:II [n=20] treated by local irradiation plus surgery plus Single agent chemotherapy i.e 5 florouracil. Group:III [n=17] treated by local irradiation plus surgery plus combination chemotherapy i.e Cis-Platinum and 5-florouracil. All patients were evaluated by endoscopic examination at 2 month intervals. This study of 59 patients [mean age 55'13 years and male to female ratio of 1:3], shows that 2 year survival is 29% and median survival period is 9 month for all the patients. For group I, median survival period = 5 month, 2 year survival =18% and complete response =17%. For group II, Median survival period = 9 months, 2 year survival =30% and complete response =20%. For group III, Median survival period = 11 months, 2 year survival = 41% and complete response = 22%. This study shows that overall survival is poor in cancer of esophagus and combined chemotherapy along with surgery and radiotherapy gives better results as compared to other two groups. Also single agent chemotherapy plus surgery plus radiotherapy give better results than radiotherapy plus surgery

study of 166 plus 80 patients: CA breast treatment complications in CENAR quetta and IRNUM peshawar during 4 years from 1991 to 1994

A retrospective study for treatment complications of 166 patients of Carcinoma Breast was carried out from 1st January 1991 to 31st December 1994 in the Centre for Nuclear Medicine and Radiotherapy [CENAR], Quetta. During this period 2742 new cases of cancer were registered. Cancer of Breast constituted 623 [22.72%] of all. It was noted that this cancer was fourth most common cancer registered in this centre and was the most common cancer in female. 166 patients come for follow up regularly for 5 years after completion of treatment. In these female to male ratio was, 9.37:1. During this period of follow up, the treatment complications were noted in these patients to highlight the subject and to recommend the factors helpful to avoid the complication and management of these complications. During this period, the same study of 80 patients was carried out in IRNUM Peshawar for the same purpose