ABSTRACT
Background: Common carotid intima-media thickness [CC-IMT] measured by ultrasonography as a non-invasive method is nowadays known as a marker for early atherosclerosis
Objectives: Survey the relationship between serum uric acid and carotid intima-media thickness considering hypertension
Materials and Methods: This study was designed as a comparative cross-sectional study in northern Iran in 2013-2014. The samples for uric acid level were taken from 90 patients. Data were collected through questionnaires and a non-invasive ultrasound technique was used to measure IMT. The analysis of data was done by one-way ANOVA and Tukey post hoc tests and logistic regression model using SPSS software version 21. The significance level was set as 0.05
Results: Patients in the 3 groups were the same age and gender. The measured carotid intima-media thickness was significantly different among the groups [p=0.004]. Using multivariate logistic regression and entering all variables. The intima-media thickness of the carotid in the group with hypertensive and hyperuricemia was significantly higher than that of the other research groups [p<0.05]
Conclusion: An association was found between serum uric acid level and increased thickness of carotid intima-media and hyperuricemia can be considered as a risk factor for atherosclerosis