ABSTRACT
The aim of this study was to evaluate the expression of two angiogenic immune-makers [CD-31 and VEGF], and one proliferative immune-marker [Ki-67] in oral pyogenic gramulomas [PG], hemangiomas [Hem] and inflammatoey gingivitis [IG]. Sixty cases of PG, Hem and IG [twenty cases each] were examined. Immunohistochemical [IHC] staining was performed based on routine techniques. The microvessel density [MVD] index was also evaluated. The male to female ratio was 1:2. The mean age was 33.3 years old [ +/- 20.52]. The reactivity percentages for all three markers [CD-31, VEGF and Ki-67] were significantly higher in PG compared to Hem [56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively]. The mean MVD in PG was also significantly higher than in Hem [26.1 +/- 0.11 vs. 13.6 +/- 0.08]. There was no statistically significant difference between PG and IG. The current study supports the common nature of pyogenic granulomas and inflammatory gingivits