D-penicillamine - induced pemphigus in a patient with Wilson disease

Pemphigus is an autoimmune blistering disease characterized by circulating autoantibodies directed against the keratinocyte cell surface. Majority of patients with pemphigus develop the disease spontaneously. However, there is a small group of patients who develop pemphigus after treatment with certain medications, of which Dpenicillamine (DPA) and captopril are the best documented. We report a case of DPA-induced pemphigus vulgaris in a young Chinese lady treated with DPA for Wilson disease.