ABSTRACT
Background: Common carotid intima-media thickness [CC-IMT] measured by ultrasonography as a non-invasive method is nowadays known as a marker for early atherosclerosis
Objectives: Survey the relationship between serum uric acid and carotid intima-media thickness considering hypertension
Materials and Methods: This study was designed as a comparative cross-sectional study in northern Iran in 2013-2014. The samples for uric acid level were taken from 90 patients. Data were collected through questionnaires and a non-invasive ultrasound technique was used to measure IMT. The analysis of data was done by one-way ANOVA and Tukey post hoc tests and logistic regression model using SPSS software version 21. The significance level was set as 0.05
Results: Patients in the 3 groups were the same age and gender. The measured carotid intima-media thickness was significantly different among the groups [p=0.004]. Using multivariate logistic regression and entering all variables. The intima-media thickness of the carotid in the group with hypertensive and hyperuricemia was significantly higher than that of the other research groups [p<0.05]
Conclusion: An association was found between serum uric acid level and increased thickness of carotid intima-media and hyperuricemia can be considered as a risk factor for atherosclerosis
ABSTRACT
Background: Stroke is a multifactorial disorder, the most common cause being arterial occlusion
Transcranial Doppler Ultrasonography [TCD] is a common non-invasive method available for assessment the arterial blood flow of the brain
Objective: Assessment the hemodynamic parameters of cerebral arteries, using TCD device in patients suffering ischemic stroke
Materials and Methods: This descriptive cross-sectional study was conducted on patients with ischemic stroke in 2014 in Iran after being approved by ethics committee of Researches and Technology Vice-chancellorship of Guilan University of Medical Sciences. After obtaining informed consent, all patients underwent TCD. Demographic details and TCD findings were recorded. Data were analysed in SPSS software 21 using independent t-test, Chi-square, and Fisher's exact tests. The descriptive results were presented as mean +/- SD and frequency
Results: A total of 102 patients [69 men and 33 women] with ischemic stroke and mean age of 63.72 +/- 12.64 years participated in this study
Among 49.02% of patients at least one hemodynamic abnormality was diagnosed. Small Vessel Disease [SVD], extracranial stenosis [ECS] and intracranial stenosis [ICS] were found in 29.41%, 20.59% and 11.76% of patients respectively
Abnormal Pulsatility Index [PI], Peak Systolic Velocity [PSV] and Mean Blood Flow Velocity [Vm] were reported in 32.25%, 20.59% and 9.8% of them respectively. A significant relationship was found between PSV parameter and also presence of ECS and gender [p = 0.047]
Moreover, SVD and abnormal PI were found significantly related to age [p - 0.002]
Conclusion: TCD results showed almost half of the patients with ischemic stroke were found to have at least one hemodynamic abnormality