ABSTRACT
Objective: Parkinson's disease is affecting millions of people worldwide. The prevalence of Parkinson's disease is 0.3% globally, rising to 1% in more than 60 years of age and 4% in more than 80 years of age and the figures are thought to be doubled by 2030. Thus, there is a great need to identify novel therapeutic strategies or candidate drug molecule which can rescue neuronal degeneration. The aim of the present study was to assess bioactive compounds found in Tulsi as potential antiparkinson activity using molecular docking and to provide scientific justification in term of its active ingredient to target protein for prevention and symptomatic treatment of diabetics. The active compounds of Ocimum sanctum is to reveal its pote Methods: ntiality by molecular docking analysis to find out its potent compound against parkinsonism which was done by Lipinski's rule in docking analysis. A wi Results: de range of docking score found during molecular docking analysis. Among the compounds Alpha-farnesene showed the highest negative value which is the best dock-score i.e., -6.2 followed by Cyclohexane-1,2,4- triethenyl (-5.9) followed by Benzene, 1, 2- dimethoxy-4-(1-propenyl) (-5.7) followed by Eugenol (-5.2). Conclusion: Alpha-farnesene and Cyclohexane-1,2,4- triethenyl are the best compounds for inhibiting of both, as it possessed best value in Molecular docking hence these are the potent antiparkinsonism agent.