ABSTRACT
Objective: To assess adherence of Palestinian hypertensive patients to and to investigate the effect of a range of demographic and psychosocial variables on medication adherence. Methods: A questionnaire-based, cross-sectional descriptive study was undertaken at a group of outpatient clinics of the Ministry of Health, in addition to a group of private clinics and pharmacies in the West Bank. Social and demographic variables and self-reported drug adherence [Morisky scale] were determined for each patient. Results: Low adherence with medications was present in 244 [54.2%] of the patients. The multivariate logistic regression showed that younger age [<45 years], living in a village compared with a city, evaluating health status as very good, good or poor compared with excellent, forgetfulness, fear of getting used to medication, adverse effect, and dissatisfaction with treatment had a statistically significant association with lower levels of medication adherence [P < 0.05]. Conclusions: Poor adherence to medications was very common. The findings of this study may be used to identify the subset of population at risk of poor adherence who should be targeted for interventions to achieve better blood pressure control and hence prevent complications. This study should encourage the health policy makers in Palestine to implement strategies to reduce non-compliance, and thus contribute toward reducing national health care expenditures. Better patient education and communication with healthcare professionals could improve some factors that decrease adherence such as forgetfulness and dissatisfaction with treatment
ABSTRACT
The aim of this study was to formulate a film-coated Valsartan/Amlodipine [VS/AM] immediate release tablets and to evaluate their in vivo release profile. VS/AM core tablets were manufactured using dry granulation method. Opadry aqueous coating dispersion was used as film coating material. Dissolution of the film coated tablets was tested in 900 ml of 0.5% SLS media, bioequivalence of tablets was tested by comparisons against the reference brand product. The ICH guidelines were used to evaluate the stability of the obtained tablets. The coated tablets were subjected to gastric pH, and drug release was analyzed using HPLC system to evaluate the efficiency of the film coat. The coated tablets had no defects. VS/AM release met the FDA guidelines for bioequivalence studies. Statistical comparison of the main pharmacokinetic parameters showed no significant difference between test and reference. These findings suggest that aqueous film coating with Opadry system is an easy and economical approach for preparing stable film coated VS/AM tablets without compromising their in vivo drugs release