Clinical Symptoms and Signs of Dry Eye Disease after Allogeneic Hematopoietic Stem Cell Transplantation

PURPOSE@#To identify the symptoms and signs of patients with dry eye disease (DED) after allogenic hematopoietic stem cell transplantation (HSCT) and analyze the correlations between these signs and symptoms.@*METHODS@#We performed a retrospective study in 96 eyes of HSCT recipients with DED. Visual acuity, intraocular pressure, Schirmer test 1 (with anesthesia), tear osmolarity, tear break-up time, Ocular staining score (OSS, Oxford), and Ocular staining disease index (OSDI) were examined before and 1, 2, and 4 months after HSCT.@*RESULTS@#A significant positive correlation was noted between changes in OSS and changes in OSDI. No ocular parameters showed significant correlations with Schirmer test values. Men more frequently described alleviation of symptoms greater than their objective results compared to women.@*CONCLUSIONS@#Subjective symptoms alone may be insufficient when diagnosing ocular graft-versus-host disease. We recommend regular ophthalmologic examination after allo-HSCT. In addition, a baseline ocular profile of tear dynamics and ocular surface parameters should be conducted before allo-HSCT.

Comparison of Corneal Astigmatism and Higher-order Aberrations between Color Light-emitting Diode Topographer and Scheimpflug Imager

PURPOSE: To compare corneal astigmatism, keratometry and corneal higher order aberrations between the light emitting diode corneal topography analyzer and Scheimpflug Imager. METHODS: This prospective study involved 45 patients (45 eyes) who visited Seoul St. Mary's hospital before cataract surgery from June 7, 2017, to August 2, 2017. For each eye, keratometry, astigmatism and its axis of cornea, higher-order aberrations were evaluated with a Scheimpflug Imager (Pentacam HR®, Oculus, Wetzlar, Germany) and a color-LED corneal topographer (Cassini®, i-Optics, Den Haag, The Netherlands). RESULTS: Astigmatism magnitude measured using Cassini® and Pentacam® showed no statistically differences but anterior and total astigmatic axes were significantly different, as measured by the two devices (p < 0.05). Anterior and total mean keratometry were statistically significantly different, as measured by the two devices (p < 0.05). J0 and J45 vectors of anterior and total cornea were statistically different (p < 0.05). In addition, Cassini® and Pentacam® showed discrepancies between total corneal astigmatism, total J0 and J45 vectors. Corneal anterior spherical aberration, vertical and horizontal coma, and oblique and horizontal trefoil aberrations were not statistically different between the two devices. CONCLUSIONS: Astigmatic axes obtained from the two devices based on different principles showed statistically significant differences. Astigmatism magnitude was not statistically different but showed a discrepancy between the two devices.

A Case of Resolved Massive Suprachoroidal Hemorrhage after Sclerotomy in Penetrating Keratoplasty Patient

PURPOSE: To report the resolution of a massive suprachoroidal hemorrhage after penetrating keratoplasty by sclerotomy. CASE SUMMARY: A 64-year-old man with a corneal opacity in the left eye underwent penetrating keratoplasty. On the first postoperative day, a massive suprachoroidal hemorrhage was detected. After two surgical drainage procedures, the suprachoroidal hemorrhage subsided and the graft survived. His visual acuity was 20/240 two months post-operation. CONCLUSIONS: We report a patient with massive suprachoroidal hemorrhage after penetrating keratoplasty that was improved by surgical drainage procedures.

Clinical Features of Patients over the Age of 60 Years Who Have Undergone Strabismus Surgery

PURPOSE: In recent years, there has been an increase in the number of strabismus operations performed on patients aged 60 years and over. This study aims to establish the characteristics and outcomes of old age strabismus. METHODS: Patients aged 60 years and over who underwent strabismus surgery between January 2011 and December 2015 were included in this study. The purpose of surgery, type of strabismus, etiology, postoperative recurrence, prevalence of general and ocular complications, and postoperative diplopia rate were reviewed. RESULTS: Ninety-eight patients aged 60 years or older were identified, and 58.2% of patients had strabismus surgery to improve diplopia, while 41.8% chose surgery for cosmetic purposes. Esotropia was the most common type of strabismus found in 40.8% of the patients, and horizontal-vertical combined type was the second highest at 29.6%. The etiology of strabismus was similarly high in both the restrictive pattern (31.6%) and neuro-paralytic pattern (30.6%). The recurrence rate after strabismus surgery was 4.1%, and the reoperation rate was 3.1%. The remnant diplopia rate after surgery in patients with diplopia was 15.8%, and the diplopia occurring rate in patients who underwent surgery for cosmetic purposes was 4.9%. No severe ocular complications such as anterior segment syndrome or eyeball rupture occurred. Anesthesia related problems did not occur in any of the patients who underwent general anesthesia. CONCLUSIONS: Strabismus in patients aged 60 years and over is an effective and safe way to improve diplopia and cosmetic status by restoring ocular alignment.