ABSTRACT
Background: The objective of present study was to assess the efficacy of dexmedetomidine over propofol in maintaining depth of anesthesia in patients undergoing elective craniotomy. Methods: Ninety patients of American Society of Anaesthesiologists (ASA) physical status 1 or 2, of either sex, with Glasgow Coma Score (GCS) 14 or 15, scheduled for elective craniotomy, were allocated in two groups, Group D and Group P. Each group consisted of 45 patients. Anesthesia was induced with propofol and maintained with nitrous oxide in oxygen, atracurium and intermittent fentanyl. Patients in Group D received continuous infusion of dexmedetomidine 0.4 μg/kg/hour which was started after induction and stopped after closure of dura in and patients in Group P received continuous infusion of propofol 100 μg/kg/min in same manner. Heart Rate (HR), mean arterial pressure (MAP), and bispectral index (BIS) were recorded and compared at specific time points which are known to have hemodynamic alterations throughout the intraoperative period. Results: Dexmedetomidine was comparable and even better (after intubation p 0.02, head pin fixation p 0.00, opening of dura p <0.00) than propofol in maintaining depth of anesthesia. It also attenuated HR and MAP at intubation, head pin fixation, skin incision, making of burr hole, opening of dura and at extubation (p 0.00). But Ramsay sedation score of patients after extubation in both groups did not differ significantly (p 0.36). No patient had recall. Conclusions: Dexmedetomidine is comparable with propofol in maintaining depth of anesthesia during elective craniotomy. It can be used as a sole anesthetic agent during craniotomy.
ABSTRACT
Background: Hemorrhagic manifestations are common with Dengue but thrombotic events are uncommonly reported. Case characteristics: 11-year-old boy who presented with ileo-femoral deep vein thrombosis associated with serologically confirmed infection with DEN1 dengue virus. Observation: There was no other history or investigation suggestive of a procoagulant state. Outcome: Successfully treated with enoxaparin and warfarin. Message: Thrombotic complications are possible with dengue infection.
ABSTRACT
We report Rhizomelic Chondrodysplasia Punctata (RDCP), a rare, autosomal recessive disorder with rhizomelic shortening of limbs, congenital cataracts and seizures but without any biochemical abnormality. The mother of the baby developed Systemic Lupus Erythromatosus (SLE) with Ro/SSA antibodies 11 months after delivery. Ro/SSA antibodies may generate calreticulin antibodies causing characteristic skeletal changes.