ABSTRACT
Gallstone [GS] formation is a multifactorial process and one of the associated factors is hyperinsulinemia. The aim of this cross-sectional study was to determine the association between size and count of gallstones, and insulin levels and resistance. The study group composed of 84 patients who have ultrasonographically confirmed gallstone[s]. Insulin level of all participants were measured and insulin resistance was calculated with the homeostasis model assessment of insulin resistance [HOMA-IR] index. All p-values < 0.05 were considered statistically significant. There were 28 patients with single stone and 56 with multiple stones. Mean insulin level was 12.54 +/- 11.66 ml/U [median 9.91 ml/U, IQR 6.33] and 56.3% of patients had insulin resistance. Mean stone size was 7.82 +/- 7.52 mm [median 6 mm and IQR 11.75]. There was a non-significant association and correlation between insulin level and size of GS [p=0.129; r =0.16]. There was significant difference between single stone group and multiple stones group, according to the insulin level