ABSTRACT
Intestinal tract plays an important role in the oral drug metabolism, and the gut microbiota which are huge amount and great variety is regard as a vital organs during drug metabolism. The gut micrbiota keep the balance normally, unless some external factors and biological factors change. The changed metabolism of drug would influence the pharmacokinetic characteristics of it. The relevant literatures in recent years about the influence of gut microbiota regulation on pharmacokinetics have been collected in this review, in order to summarize the current research method of pharmacokinetics by gut microbiota and influence of gut microbiota regulation on pharmacokinetics caused by pathologically induced by metabolic disorders, endocrine dyscrasia and insanity, physiology induced by the difference in race and age and drug combination like Chinese traditional medicine, antibiotics and probiotics. This paper not only makes the combination of pathophysiological state and pharmacokinetic characteristics by gut microbiota, but also provides a reference for further research about the influence of gut microbiota regulation on pharmacokinetic characteristics.