1.
Acta Pharmaceutica Sinica
;
(12): 263-267, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-250632
ABSTRACT
A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).