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Objective To investigate the diagnostic value of High-Sensitive Troponin T(hs-TnT)in acute myocardial infarction(AMI). Methods One hundred and sixty nine patients with serum hs-TnT concentration≥0.014 μg/L in early hospitalization were enrolled in this study.The ROC curve was used to compare the concentra-tion of hs-TnT with four heart enzyme(CK,CK-MB,LDH,AST)on the diagnostic efficacy to AMI. The differ-ence of hs-TnT in different clinical data groups were investigated using Mann-Whitney U rank test.Then the correla-tion between hs-TnT and Gensini score of Coronary angiography was investigated using the Spearman rank correla-tion test.Results The concentration of hs-TnT in patients with chest pain was significantly higher than that in non-AMI group(P<0.05).The AUC of each ROC curve was hs-TnT(0.806)>CK-MB(0.792)>CK(0.780)>AST (0.704)> LDH(0.684). The optimal diagnostic point of hs-TnT was 0.152 ug/L(sensitivity 0.659,specificity 0.894,Yuden index 0.553).There was a positive correlation between hs-TnT and Gensini scores in men,age>65 years old and the chest tightness group(P < 0.05). Conclusion The hs-TnT is better than four heart enzyme in early diagnosis of AMI and benefit early treatment of AMI.
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Objective To investigate the detection rate and characteristics of thyroid nodules in medical personnels.Methods A total of 830 medical personnels from the First Affiliated Hospital of Guangzhou University of Chinese Medicine who participated in physical examination and completed thyroid high frequency color Doppler ultrasound examination from January to December 2014 were enrolled in this study.The prevalence rate of thyroid nodules in the 830 medical personnels was investigated.Additionally,the differences in detection rate,size,nature,number of nodules were compared in gender and age.Results A total of 384 thyroid nodules were detected,including 123 males (the detection rate was 40.07％) and 261 females (the detection rate was 49.90％).The detection rate of thyroid nodules was increased with age (P＜0.05).The single nodule was detected in 194 cases (50.52％) of patients,and multiple nodules were present in 190 cases (49.48％) of patients.The proportion of multiple nodules was gradually increased with age.In male and female patients,thyroid nodules were mainly small ones.Among the 384 cases of patients,81 cases (21.09％) were found thyroid nodular calcification,including 28 cases (34.57％) of male patients and 53 cases (65.43 ％) of female patients.Conclusion The detection rate of thyroid nodules of medical personnels in this hospital is high,and the prevalence rate is increased with age.The thyroid color ultrasound should be one of the routine physical examination items.
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Objective To investigate the detection rate and characteristics of thyroid nodules in medical personnels.Methods A total of 830 medical personnels from the First Affiliated Hospital of Guangzhou University of Chinese Medicine who participated in physical examination and completed thyroid high frequency color Doppler ultrasound examination from January to December 2014 were enrolled in this study.The prevalence rate of thyroid nodules in the 830 medical personnels was investigated.Additionally,the differences in detection rate,size,nature,number of nodules were compared in gender and age.Results A total of 384 thyroid nodules were detected,including 123 males (the detection rate was 40.07％) and 261 females (the detection rate was 49.90％).The detection rate of thyroid nodules was increased with age (P＜0.05).The single nodule was detected in 194 cases (50.52％) of patients,and multiple nodules were present in 190 cases (49.48％) of patients.The proportion of multiple nodules was gradually increased with age.In male and female patients,thyroid nodules were mainly small ones.Among the 384 cases of patients,81 cases (21.09％) were found thyroid nodular calcification,including 28 cases (34.57％) of male patients and 53 cases (65.43 ％) of female patients.Conclusion The detection rate of thyroid nodules of medical personnels in this hospital is high,and the prevalence rate is increased with age.The thyroid color ultrasound should be one of the routine physical examination items.
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The NLRP3 inflammasome, a protein complex belonging to the family of nucleotide-binding and oligomerization domain like receptors (NLRs), plays a vital role in the innate immune system. It promotes pro-caspase 1 cleavage into active caspase-1, which contributes to maturation and releases of IL-1β and IL-18 in response to the harmful signals and participates in the host immune response and sterile inflammation. Recently a large number of studies have shown that NLRP3 inflammasome closely relates to the pathogenesis of the vascular diseases. NLRP3 inflammasome, which involves in the sterile inflammation of the vascular wall, plays an important role in the pathogenesis of main, middle and small arteries.
Subject(s)
Humans , Caspase 1 , Allergy and Immunology , Metabolism , Gene Expression Regulation , Genetics , Allergy and Immunology , Inflammasomes , Allergy and Immunology , Inflammation , Genetics , Interleukin-18 , Genetics , Allergy and Immunology , Interleukin-1beta , Genetics , Allergy and Immunology , NLR Family, Pyrin Domain-Containing 3 Protein , Allergy and Immunology , Signal Transduction , Genetics , Allergy and Immunology , Vascular Diseases , Genetics , Allergy and ImmunologyABSTRACT
Objective:To explore and discuss the differences of pregnancy contents and inform formats in in-formed consent form ( ICF) for the drug clinical trial between China and foreign countries. Methods:We collected Chinese and foreign ICFs for drug clinical trial that had been audited by the Ethics Committee of the third Xiangya Hospital for the past five years. Based on the relevant domestic and foreign law, we concluded the element stand-ards and inform formats about pregnancy inform. By analyzing the integrity of the whole elements, the inform rate of every element and the using rate of every inform format, we compared the differences of pregnancy contents and in-form formats between Chinese ICFs and foreign ICFs. Results:The total number of ICFs was 177 in this study, in-cluding 107 Chinese ICFs and 70 foreign ICFs. The integrity rate of pregnancy in Chinese ICFs was statistically lower than them in foreign ICFs (19% vs. 56%, P=0. 000). Compared with foreign ICFs, the low informed ele-ments were the study of the pregnancy risk (32% vs. 73%, P=0. 000), the pregnancy test during the following-up period (33% vs. 56%, P=0. 002) and the measurements for contraception (22% vs. 53%, P=0. 000). Conclusion:The integrity level of pregnancy content in Chinese ICFs was lower than that of the foreign ICFs. And the three elements including pregnancy risk study, pregnancy test during the following-up period and measure-ments for contraception was obviously defected. Pregnancy informing forms of informed consent in China was inferi-or to abroad.
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Objective To observe the effects of early rehabilitation training on endothelial progenitor cells (EPCs),stromal cell-derived factor alpha 1 (SDF-lα) and motor function recovery in hemiplegic patients with acute cerebral infarction.Methods Fifty hemiplegic patients after a first acute cerebral infarction were randomly divided into a control group (n =25) and an experimental group (n =25).Both groups of patients were given routine drug therapy,while the experimental group also received early rehabilitation (within 48 hours of onset).EPCs and SDF-1α levels in peripheral blood were measured before and after one week of treatment,and Fugl-Meyer assessments and modified Barthel index scoring were conducted at admission and after three months of treatment.Results There was no difference between the 2 groups before the treatment.After a week of treatment,however,the EPC and SDF-1α values of both groups had increased,with those of the experimental group increasing significantly more than in the control group.Spearman rank correlation analysis showed that the increase in EPCs was positively correlated with the SDF-1α increment in the first week.After 3 months of treatment,the average FMA and MBI results of the experimental group were significantly better than those of the control group.Conclusion Early rehabilitation training can help to further improve the recovery of motor function for hemiplegic patients after acute cerebral infarction.This may be related to its effect in upregulating the expression of SDF-1α,thus contributing to the mobilization of EPCs in the bone marrow.
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Objective To discuss the relation and differences among spleen-deficiency syndromes, stomach-deficiency syndromes and spleen-stomach deficiency syndromes.Methods Terms about spleen-stomach deficiency syndromes in the book ofLin Zheng Zhi Nan Yi Anwere screened. Syndrome names about “spleen deficiency”, “stomach deficiency”, “stomach-yang deficiency”, “tu deficiency”, “spleen-stomach deficiency”, “middle-jiao deficiency”, “yang-ming deficiency”, and “tai-yin deficiency” should be included in this study. And then medication and compatibility of medicines of spleen-deficiency syndromes, stomach-deficiency syndromes and spleen-stomach deficiency syndromes were determined according to the main efficacy of the medication and compatibility of medicines. Relevant data were standardized and then database was built. Apriori algorithm in SPSS Clementine12.0 was used to conduct data mining.Results Totally 421 relevant cases were collected in this study, involving 525 prescriptions (92 spleen-deficiency syndromes, 276 stomach-deficiency syndromes and 157 spleen-stomach deficiency syndromes). 11 medication association rules about spleen-deficiency syndromes, 38 about stomach-deficiency syndromes, and 28 about spleen-stomach deficiency syndromes were found based on data mining. ConclusionMost prescriptions for spleen-stomach deficiency syndromes are “warm dryness, cool and moister, sweet and warm to tonify the midde jiao”, which embody Ye’s medication features that emphasizes treating spleen and stomach separately, the differences of lifting spleen and dropping stomach, and in nourishing yin and tonifying yang.
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Serum tumor biomarkers are significant for the early diagnosis and treatment,preoperative evaluation,prognosis prediction and relapse surveillance of endometrial carcinoma.Recently,serum CA125 and human epididymal secretory protein 4 are widely recognized as closely related with staging,metastasis and prognosis of endometrial cancer.In addition,the serum miRNAs are characterized by their features of high stability and specificity.Omics studies will be helpful for the general assessment of the initiation and progression of endometrial cancer.Insights into these two aspects will facilitate the identifications of new biomarkers with higher sensitivity and specificity for endometrial carcinoma.
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Objective To explore the effect of electroacupuncture on CD 34 +VEGFR2 +endothelial progenitor cell (EPC)-derived vessels and stromal cell-derived factor-1α(SDF-1α)/CXCR4, and study its mechanism of promoting an-giogenesis in hippocampus after focal cerebral ischemia /reperfusion .Methods A total of 180 healthy male adult Sprague Dawley (SD) rats were randomly divided into sham operation (sham) group, model (I/R) group, electroacupuncture (I/RE) group, I/RE plus AMD3100 (A specific antagonist of CXCR4) group (I/REA) and AMD3100 (I/RA) group. The rats received filament occlusion of the right middle cerebral artery for 2 hours followed by reperfusion .Electroacupunc-ture was applied to “Baihui” (GV20)/“Siguan” (Hegu LI 4/Taichong LR 3) acupoints for 30 min, once a day.The mR-NA expression of SDF-1αand CXCR4 were detected by reverse transcription-polymerase chain reaction ( RT-PCR) .Double immunofluorescence was used to stain CD 34 +VEGFR2 +EPC-derived vessels.Results Compared with the sham group, the mRNA expressions of SDF-1αand CXCR4 were significantly upregulated in I/R and I/RE group ( P<0.05 ) , but that in I/RE group was more significantly increased than I/R group(P<0.05).In addition, the mRNA expression of SDF-1αand CXCR4 were highly increased on day 1 in the I/REA group than that of I/RE group, but decreased than that of I/RE group on day 7 after reperfusion (P<0.01).CD34 +VEGFR2 +EPCs-derived vessels were obviously increased on 3d and 7d in the I/RE group compared with that of the I/R group, and significantly decreased on 7d in the I/REA group compared with that of the I/RE group ( P<0.01) .Conclusions Electroacupuncture can effectively promote an-giogenesis through upregulating the expression of SDF-1αand CXCR4 in rat ischemic hippocampus after focal cerebral is-chemia/reperfusion.
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Objective To analyse the clinical practicability and significance of fertility-sparing surgery for women with recurrent borderline ovarian tumors ( BOT).Methods The clinical and pathological recordings of 12 patients suffered from recurrent BOT in the Obstetrics and Gynecology Hospital of Fudan University from Jan.2002 to Dec.2012 were analyzed retrospectively.The menstruation situation , fertility function , recurrence rate and survival after second conservative surgery were collected and analyzed .Results The average onset age of these 12 patients was 26 years, and none of them had procreation before the second operation.The pathological diagnosis were still BOT and the recurrent sites of 10 patients were still restricted to the ovaries.Of the 12 cases, 8 cases of them had normal menstruation functions and 4 cases had less menstrual volumes or longer menstrual periods.Among 6 cases desired for pregnancy after the second operation,4 cases of them were successful.The spontaneous pregnancy rate was 4/6.The mean duration of follow-up was 53 months(range:23-97 months).All recurrent BOT, three cases developed recurrence once more,two cases of them were just be hinted by B ultrasounds and only one cases was approved to be BOT again by a once more surgical pathology.But no disease related deaths occurred.Conclusions The second fertility-sparing surgery may be feasible for women with recurrent BOT who are young and strongly desired for preservation of fertility.The spontaneous pregnancy rate is satisfactory.However, carefully follow-up is still needed.