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Objective To examine visceral fat in pathogenesis of coronary heart disease in male adults .Me thods 64-slice spiral CT were measured to separate 50 patient into the following 2 groups:CAD( n =26)and healthy control( n =24).Results Fasting insulin concentration, Insulin resistance index, cholesterol, triglyceride, waist circumference and visceral fat were higher in coronary heart disease group while the lower in healthy control group ( P <0.01 ) .The levels of fasting insulin concentration was posi-tively correlated with visceral fat ( r =0.779 , P <0.01 ) .Conclusions Coronary heart disease is characterized with insulin resist-ance.Fasting insulin concentration and visceral fat are higher in coronary heart disease group than the healthy group , and they may be involved in the pathogenesis of insulin resistance .
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Objective To investigate the variation of the oxidative stress status in type 2 diabetes mellitus(T2DM)patients with acute coronary syndrome (ACS)and significance.Methods Eighty -nine patients hospitalized in our department from September 2012 to April 2014 were divided into three groups: T2DM control (group DM), T2DM with coronary artery disease(group DM-CAD) and T2DM with acute coronary syndrome (group DM-ACS).Blood glucose,HbA1C,Lipids,serum Malondialdehyde (MDA) level, su-peroxide dismutase(SOD) activity, glutathione peroxidase (GSH-Px) activity and total anti-oxidation capacity(T-AOC) were deter-mined.Results Blood glucose、HbA1C and Lipids were similar in three groups ( P >0.05).Compared to group DM and group DM-CAD, serum MDA levels in group DM-ACS were significantly higher( P <0.05), while SOD、GSH-Px activities and T-AOC were sig-nificantly lower than those in group DM and group DM -CAD( P <0.05).Conclusions The oxidative stress level being significantly increased in T2DM patients with ACS.
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Objective To investigate the therapy effect of deanxit combined with large dose of oryzanol in the treatment of post stroke depression(PSD) and anxiety in elderly male.Methods Sixty cases of PSD and anxiety patients were divided into three groups by random number table method with 20 cases in each,deanxit group treated with deanxit,oryzanol group treated with oryzanol,and combination group treated with deanxit and large dose of oryzanol,a total of 4 weeks.Before and after 4 weeks treatment respectively using Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) scores.Results The HAMD and HAMA scores before treatment in three groups had no statistical significance (P ＞ 0.05).Compared with before treatment,HAMD and HAMA scores in three groups after treatment were significantly lower (P＜ 0.01).HAMD scores in combination group were improved better than those in deanxit group and oryzanol group [(12.85 ± 3.69) scores vs.(15.30 ± 3.28),(18.65 ± 3.13) scores](P＜ 0.01),and deanxit group were better than oryzanol group(P＜ 0.01).HAMA scores in deanxit group and combination group were lower than those in oryzanol group [(8.65 ± 3.33),(7.25 ± 3.34) scores vs.(10.65 ± 3.18) scores] (P ＜0.01).Conclusion Deanxit combined with oryzanol is effective in the treatment of PSD and anxiety in elderly male.
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ObjectiveTo investigate the effects of Tangmaikang on oxidative and carbonyl stress in streptozocin-induced diabetic rat kidneys,and to also explore their reno- protecting mechanisms in diabetic rats.MethodsRats were randomly divided into three sub-groups:normal control (group A),diabetic control (group B) and diabetic with Tangmaikang (group C).Blood glucose,blood lipid,HbAlC,kidney to body weight ratio and urinary protein excretion were measured after 12 weeks.Malonyldialdehyde (MDA)level,superoxide dismutase (SOD) activity,glutathione peroxidase (GSH-Px) activity,total sulfhydryl group and protein carbonyl levels in renal tissue were also determined.ResultsCompared to group A,kidney to body weight ratio,urinary protein excretion,MDA,and protein carbonyl levels in group B were significantly higher,while SOD and GSH-Px activities and total sulfhydryl group level were significantly lower than those in group A.Kidney to body weight ratio,urinary protein excretion,MDA,and protein carbonyl level in group C were significantly lower than those in group B.SOD and GSH-Px activity in group C were higher than those in group B.ConclusionTangmaikang can prevent renal hypertrophy and decrease urinary protein excretion in diabetic rats.The renoprotective effects of this drug may be related to his ability to inhibit oxidative and carbonyl stress.
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Objective To investigate the effects of epalrestat on oxidative and carbonyl stress in streptozocin-induced diabetic rat kidneys, and to also explore their reno -protecting mechanisms in diabetic rats.Methods Rats were randomly divided into three sub-groups:normal control (group A),diabetic con-trol (group B) and diabetic with epalrestat (group C). Blood glucose, blood lipid, HbA1C, kidney to body weight ratio and urinary protein excretion were measured after 12 weeks.Malonyldialdehyde (MDA) level, superoxide dismutase(SOD) activity, glutathione peroxidase (GSH-Px) activity, total sulfhydryl group and protein carbonyl levels in renal tissue were also determined .Results Compared to group A , kidney to body weight ratio , urinary protein excretion , MDA, and protein carbonyl levels in group B were significantly higher , while SOD and GSH-Px activities and total sulfhydryl group level were significantly lower than those in group A.Kidney to body weight ratio , urinary protein excretion , MDA, and protein carbonyl level in group C were significantly lower than those in group B .SOD and GSH-Px activity in group C were higher than those in group B .Conclusion Epalrestat can prevent renal hypertrophy and decrease urinary protein excretion in diabetic rats .The renoprotective effects of this drug may be related to his ability to inhibit oxi-dative and carbonyl stress .