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Objective:To investigate the significance of periodontal treatment on the levels of MMP-3 and IFN-γin the serum of patients with oral lichen planus(OLP) and chronic periodontitis(CP) before and after treatment.Methods:60 patients with erosion OLP and CP were divided into 2 groups randomly (n =30).The patients in experimental group received basic periodontal treatment combined with drug therapy,those in control group received drug therapy only.Before and after treatment the periodontal indexes of PD,AL,BI and PLI were measured in the experimental group,the levels of MMP-3 and IFN-γ in serum were tested by ELISA in the 2 groups,the differences of the data between 2 groups were statistically analysed.Results:After treatment the periodontol indexes were decreased in the experimental group(P ＜ 0.05),the serum MMP-3 and IFN-γ levels were lower than those before treatment in 2 groups(P＜0.05),and the decline of MMP-3 and IFN-γ in experimental group was more obvious than those in the control group (P＜0.05).Conclusion:Periodontal initial therapy has positive influence on the treatment of OLP and can reduce the level of inflammation.
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BACKGROUND:As one of common oral diseases, periodontitis is the leading cause of tooth loss in adults. OBJECTIVE:To review the research progress on periodontitis treatment. METHODS:A computer-based search was performed on the PubMed database and CNKI database for articles addressing periodontitis treatment. The key words were“periodontitis, treatment, tissue engineering, gene engineering”in English and Chinese, respectively. Final y, a total of 57 articles were included to review. RESULTS AND CONCLUSION:Currently, the majority of scholars are stil focus to improve periodontal tissue, promote the regeneration and repair of periodonttal tissue. With the development of tissue engineering and gene technology in recent years, periodontitis has been treated from multiple perspectives and multiple aspects, to solve the problems of patients with periodontitis. However, some treatment methods are stil in their early stage and need in-depth research.
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We analyzed coupling expansion process of three different structures of stainless steel (SUS-316LI) stents by using finite element method (FEM) simulation in this study. Firstly we made specific analysis and comparison between three stents of deformation and stress-strain distribution in the coupling expansion process and then we described the shortening rate, radial bounce rate, expand nonuniformity, safety factor and other biological mechanics performance of the three stents quantitatively. And finally we analyzed the influencing factors and the best structure of the three kinds of the stainless steel stent comprehensively. Through all the processes, we have verified the rationality of the finite element simulation result by using the expansion test in vitro.