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China Pharmacy ; (12): 1211-1215, 2023.
Article in Chinese | WPRIM | ID: wpr-973621

ABSTRACT

OBJECTIVE To investigate the effects of Angelica sinensis polysaccharide on the apoptosis of cardiomyocytes in diabetic KK-Ay mice. METHODS KK-Ay mice were randomly divided into model group, metformin group (200 mg/kg) and A. sinensis polysaccharide high-dose, medium-dose and low-dose groups (400, 200 and 100 mg/kg); C57BL/6J mice were included in blank group, with 8 mice in each group. Each group was given relevant medicine intragastrically or normal saline, once a day, for consecutive 4 weeks. After the final administration, the levels of fasting glucose, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and insulin (INS) were detected; the protein expressions of B-cell lymphoma 2 (Bcl-2), cleaved- caspase-3, apoptosis signal-regulated kinase 1 (ASK1), phosphorylated c-Jun N-terminal kinase (p-JNK), phosphorylated inositol- requiring enzyme 1α (p-IRE1α) in myocardium, and apoptosis in cardiomyocytes were also detected. RESULTS Compared with model group, the fasting glucose, TC and LDL-C content, apoptotic rate of cardiomyocyte, protein expressions of p-JNK and p- IRE1α, ASK1, cleaved-caspase-3 were significantly lower in the metformin group and A. sinensis polysaccharide medium-dose, high-dose groups; INS level and relative expression of Bcl-2 protein were significantly increased (P<0.05 or P<0.01). CONCLUSIONS A. sinensis polysaccharide can improve the levels of blood glucose and blood lipid and inhibit cardiomyocyte apoptosis in diabetic KK-Ay mice, and the mechanism may be related to the inhibition of IRE1/ASK1/JNK signaling pathway.

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