ABSTRACT
A Prospective observational study was carried at Fatima Jinnah Medical College, Lahore on 100 female patients with histologically verified breast cancer and 50 age and sex matched control subjects with no history of breast cancer. The objective was to ascertain geographical/biochemical diversity of findings breast cancer among developed and developing countries. Physical findings as well as biochemical findings in serum of both patients and control subjects was carried out by standard automated calorimetric method. Variations in both physical findings and biochemical parameters was observed and compared with control subjects and with studies of different developed countries. It was concluded that seventy five percent of breast cancer in Pakistani women occurred with no recognized major risk factor. Further research is needed in the population of different city of Pakistan to find out the actual risk factor responsible for the disease