ABSTRACT
Type II diabetes is a complex, multi factorial disorder involving both impaired insulin release and end organ in sensitivity. Obesity is an extremely important diabetogenic influence and approximately 80% of type 2 diabetic patients are obese. The of onset of disease is usually after 40 years. Many persons in this age show an exaggerated insulin resistance which may be due to reduction in number of insulin receptors. SETTING: Department of Biochemistry, Fatima Jinnah Medical College, Lahore. MATERIAL AND METHODS: Study was undertaken to determine the socio-demographic variables, disease variables, biochemical parameters, protein pattern by electrophoresis and urinary parameters like glucose, fructose etc. Blood sugar, before and after breakfast a s well as blood urea were significantly increased in both male and female patients. Level of protein, albumin, globulin and AG ratio were decreased in patients of both sexes but shows no significant difference. Urinary parameters, such as glucose and fructose appeared in urine of patients. Excretion of glucose in urine was noted in all patients and both glucose and fructose excretion in some. Serum electrophoresis of both male and female patients shows that a protein band of 40-45 Kda is either missing or exhibits lower concentration when compared with electrophoretic profile of normal subjects