Thiosemicarbazone and thiazolylhydrazones of 1-indanone: as a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents

This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC50 esteems going from 5.1+/-1.3 - 78.8+/-4.6µM/mL. Compound 1 [IC50 =5.1+/-1.9µM] displayed potent result than standard ibuprofen [IC50 = 11.2+/-1.9 µM]. In antiplatelet aggregation assay, five compounds 1, 5, 6, 8 and 11 were observed to be dynamic with IC50 esteems observed in the range of 38.34-255.7+/-4.1µM, whereas, aspirin [IC50 = 30.3+/-2.6 µM] was used as standard. However, compound 11 was found to be good active for both anti-inflammatory and antiplatelet aggregation activities [IC50 = 13.9+/-4.9µg/mL] [IC50 = 38.60+/-3.1µM], respectively

[Asthma and its correlates in primary school children in Shiraz]

Introduction: Asthma is one of the most common chronic conditions in children

Objective: The present study was based on target population. After the study of prevalence, determination of asthma was matched by case- control method to identify correlates in primary school children aged 6-12 years in Shiraz [Southern Iran]

Materials and Methods: This study was conducted in 2228 primary school children. The children were selected using two-stage random sampling from the four educational districts of Shiraz. A screening questionnaire was completed for each child. The consultant physician examined the children with positive result. After diagnosis of asthma, control group was selected by using matching method [age-sex-school]. Conditional Logestic Regression determined the correlates of asthma

Results: The most important results were as follows: Prevalence of diagnosed asthma in primary school children estimated as %102 [boys: 1.19% - girls: 1.13%] with no significant difference. There was no significant association between asthma and birth order, social class, parent's education, mother's occupation and duration of breast-feeding. An increased risk of childhood asthma was associated with familiar history of allergic rhinitis [P<0.04], familial history of asthma [P< 0.01], history of allergy in children, [P<0.007] and exposure to smoking [P<0.016]

Conclusion: Our study confirmed that familial atopic diseases and exposure to smoking were significant predictors of childhood asthma in Shiraz children

Age at natural menopause and its determinants in Shiraz

The mean age at natural menopause among women of Shiraz in relation to socio-demographic factors was calculated. The data were obtained from a population-based, cross-sectional study carried out in the year 2000. Interviews were carried out and observations made with women in Shiraz, who had undergone a natural menopause. Chosen at random basis from a sample using postal zones housing framework. The most important results include mean +/- SD age at menopause in the population of 48.3 +/- 5.3 years [95% CI: 47.97-48.62] with a median of 49 years. Groups of women with an average early menopause were those with never married [44.7 years, P < 0.006], low income level [47.4 years P < 0.002], low social class [45.8 years, P < 0.000], tobacco use [47.9 years, P < 0.014] non consanguine husband [48.1 Year, P < 0.027]. This phenomenon must be documented in Iran because of it's strong links with morbidity and mortality of the growing number of women who are reaching advanced ages and whose survival is calculated at a quarter century after menopause

[Obesity pattern of south Iranian infants and their parents]

Obesity [a scaled weight-by-height index] charts of a cohort of 3 17 healthy infants and their parents living in Shiraz [Southern Iran] are presented, and the familial pattern of infant's obesity with that of its parents explored. An adjusted weight-for-height was used to develop power type obesity indices, Ip=WMP. Polynomial modelling was used by applying the HRY [Healy, Rasbash, Yang] nonparametric method to estimate agerelated smoothed centiles of obesity. Principal component analysis [PCA] was applied to analyze the data as continuous variables to analyses familial pattern of parent-infant obesity structurally. The optimal value of p was found to be 2.5 for infants and 1 for their parents. No more than cubic and quadratic polynomials were needed to fit obesity-for-age smoothly for infant and their parents respectively. Infant obesity increases from birth to six months of age and decreases later on to the age of 21-months when it becomes stable. Parent obesity lies below the NCHS standard. Obesity indices and circumferences sizes were reduced to two principal components interpreting infants as well as family obesity. A structural analysis indicates a direct relationship between obesity of parents and infants. A local standard for assessing obesity in clinical practice as well as community health programmes in Iran is of urgent need, for which our data serves this purpose

Infants body mass index reference curves for Iran

Background: the body mass index, defined as weight/height2, is often used to monitor childhood obesity. The BMI offers a reasonable measure of fatness in children. This study was designed to document the distribution of body mass index [BMI] in healthy south Iranian infants and present local BMI reference values

Methods: a cohort of 317 healthy full term neonates [153 boys and 164 girls] were selected randomly from all maternity hospitals of Shiraz [southern Iran] and were followed for two years from their birth. BMI centiles based on the original height and weight data were derived using the HRY method

Results: BMI rised in the first six months of infants life, followed by a mild fall up to the age of 21 months, then stayed almost stable. Age related cut off points were assigned to the 5th centile for thinness, 85th centile for overweight and 95th centile for obesity, which were appropriate for classifying the degree of fatness. Girls BMI centiles lie below boys

Conclusions: Shiraz infants were relatively free of obesity. BMI centiles are suitable tools to monitor infantile obesity and serve as a baseline. However, they should be studied with other obesity indices such as weight-for-height and scaled weight by height

Growth modeling of school children in Iran using Shiraz data

Centile values and growth charts for height, weight and arm circumference are presented for school children aged six to 12 years in Shiraz [Iran]. The smooth centile values have been derived from the raw data by Healy's nonparametric method. Girls grow faster than boys. Homogeneity of data with population structure and universal rationing imply that these norms are likely to be appropriate to all urban children in Iran. These observations are in favour of using local standards in clinical diagnosis and nutritional screening in order to develop efficient and effective health programmes