A Novel Natural Product for Bone Regeneration in Dentistry - A Review

Herbal medicine has been regarded as a safer and more natural method to promote health and alleviate illness and has gained notable popularity. Plants continue to be the primary source of new chemicals and drugs and hence play a pivotal role in the continual improvement in therapeutic medicine. India has a huge asset of indigenous plants and minerals which have been broadly used for therapeutic claim. One such plant which has immense benefits derived from it is Cissus quadrangularis [CQ] colloquially known as hadjod or pirandai. CQ is one of the most significant plants. However, practically the entirety of its parts are utilized in medicine among which seeds, stems, roots, and shoots are the most significant parts. Concentrates and powders of Cissus quadrangularis have been utilized for a long time to aid bone and tissues healing, as an antioxidant, for relieving pain & swelling, to fight against infection, as an anabolic, and also to help in weight reduction. The most important usage has been for bone regeneration and fracture healing. Numerous studies have been done to prove its pharmacological effects and to substantiate its use clinically. The aim of this review is to elaborate on CQ, its ethnopharmacology, phytochemistry and principle constituents, pharmacological actions, formulations and to review previous literature such as animal studies, in vitro studies and clinical trials to understand in detail about the applications of this plant in medicine and dentistry

Chronic Hypoxemia in a Child: Thinking Outside the Box.

Background: Chronic hypoxemia is generally attributed to primary cardiac or pulmonary entities. Case characteristics: A 9-year-old boy presenting with cyanosis, clubbing and hypoxemia, without icterus or hepatosplenomegaly. Cardiovascular and respiratory system examinations were normal. Outcome: He was diagnosed as type IB Abernethy malformation, a rare cause of hepatopulmonary syndrome. Message: Pediatricians should consider hepatopulmonary syndrome in the differential diagnosis of chronic hypoxemia, even in the absence of jaundice or hepatosplenomegaly.

Xanthogranulomatous Pyelonephritis (XGPN) in a Child with Multiple Ureteric Calculi.

Xanthogranulomatous pyelonephritis (XGPN) is an unusual suppurative granulomatous reaction to chronic renal infection, often in the presence of chronic obstruction, characterised histologically by granulomatous reaction with giant cells and foamy histiocytes1. XGPN is rare in children2. We report a case of XGPN, in a child with multiple lower ureteric calculi. An 11 year old male child presented to us, with features suggestive of acute pyelonephritis of two months duration.complete evaluation including contrast CT of the abdomen a diagnosis of XGPN was made. As the renal unit in question was non functional, he was treated successfully by subcapsular nephrectomy. This case is presented to emphasise the fact that, it is very important to diagnose XGPN early and differentiate it from chronic pyelonephritis. Prolonged antibiotic therapy and surgery is invariably required to relieve the obstruction and to eradicate the infection in patients with XGPN.

Split-hand/feet malformation in three tamilian families and review of the reports from India.

Split‑hand/foot malformation (SHFM) is a rare condition which can be either syndromic or nonsyndromic. We report three unrelated pedigrees, one with autosomal dominant (AD) inheritance and the other two with autosomal recessive (AR) pattern. We also briefly review the published reports from India.

Sclerosterosis (Truswell-Hansen disease).

Sclerosteosis or Truswell-Hansen disease is a rare autosomal recessive disorder characterized by dense bones, tall stature, and syndactyly. Most of the reports are from South Africa. Here we report the first such case from India.