ABSTRACT
Introduction: Stroke is a leading cause of disability worldwide. Cognitive functions and, in particular, executive function is commonly affected after stroke, leading to impairment in daily activities. Previous studies have shown confiicting evidence regarding the incidence of executive dysfunction in patients with right or left hemispheric strokes. Few studies have shown that executive dysfunction is more prevalent in right hemispheric strokes. Aims and Objectives: 1. To study the executive dysfunction in patients with Right Hemispheric strokes. 2. To compare the impairment of executive functions with the Vascular territory involved Methods: This was a prospective observational study which included 100 patients admitted to a tertiary care center from January 2021 to August 2021. After Institutional EC clearance, patients with Right-Hemispheric ischemic stroke on neuro-imaging (CT or MRI) were included in the study. Demographic data, clinical history, neurological examination and etiological workup like echocardigraphy, carotid and vertebral artery doppler, CT/MR angiography were performed. Executive function was tested clinically using go-no-go test, digit-span test, trail making test, N-back test, Rey-osterreith complex ?gure test and clock drawing test. Data was entered to a pre-formatted data sheet and analysed. Results: The mean age of the included patients was 58.76years, 54 patients were male, Sixty-nine patients had anterior circulation stroke, 31 had posterior circulation stroke. Forty three patients had executive dysfunction as evidenced by abnormal go-no-go test (n=22), digit-span test(n=35), trail making test(n=10), N-back test(n=23), Rey-osterreith complex figure test(n=38) and clock drawing test(n=29). Executive dysfunction was more prevalent in anterior circulation strokes (n=37) as compared to posterior circulation strokes (n=6) (p=0.001) Executive dysfunction Conclusion: was a common finding in patients with right hemispheric stroke and was significantly higher in patients with anterior circulation strokes
ABSTRACT
Introduction: Rat killer paste (yellow phosphorous) is one of the most common forms of poisoning in South India. It causeshepatotoxicity. No specific antidote has been found. Recently, N-acetylcysteine is used as supportive therapy in many casesof acute liver failure.Aim: This study aims to evaluate the effectiveness of early N-acetylcysteine in preventing the rat killer paste poisoning.Methods: Patients who ingested rat killer paste poison and age >12 years were included in the study. Patients having jaundice,liver disease, and age <12 years were excluded from the study.Results: Among 30 patients studied, five patients died, seven patients developed hepatitis, one patient developed acute kidneyinjury with hepatitis, and one patient developed hyponatremia.Conclusion: Early initiation of N-acetylcysteine had a significant impact in reducing mortality.