Serum level of lactate dehydrogenase, homocystein, hemoglobin and platelet in preeclampsia

Pre-eclampsia affects approximately 5-8% of pregnant women. The aim of this study was to compare the serum level of Lactate dehydrogenase [LDH], Homocystein, Hemoglubin and platelet in pregnant women diagnosed as pre-eclampsia and a normal group in Gorgan city, Northeastern Iran from 2007-2008. In this case control study, 50 cases of pre-eclampsia were compared with the control group women hospitalized in Dezyani hospital. Pre-eclampsia criteria were: Blood pressure more than or equal to 140/ 90 mm hg and Proteinuria greater or equal to 300 mg/ 24 hours urine sample in the third trimester. Hemoglobin, platelet, LDH and hemocystein were measured. Data were analyzed by the mean of SPSS-14 program and Chi-2 or t-student were used. The difference of BMI and family incomes was significant between two groups [P-value<0.01]. LDH level was not statistically different between healthy and pre-eclamptic individuals. Six cases [12%] in controls and 9 cases [18%] in pre-eclamptic group had thrombocytopenia [P-value>0.01]. Hemocystein level was more than normal range in five patients with pre-eclampsia [P-value<0.001]. In this study, hemocystein level was significantly higher in pre-eclampsia patients but LDH, hemoglobin and platelet level had no significant difference

Molecular epidemiology of high-risk types of human papillomaviruses [16, 18] in pap-smear, the North East of Iran

Cervical Cancer is one of the most important and commonly diagnosed types of cancer in females. There are different causes of cervical cancer, amongst which recurrent and persistent infection with HPV types 16 and 18 are the most renowned ones. These genotypes are the main factors in 99% of cases in developed countries and 70% in developing ones. Due to the importance of these viruses in cervical cancer, molecular detection of HPV and its high risk genotypes in Gorgan was designed. Pap smears and swabs specimens were taken from 308 women. Papanicola staining method and cytology were used. Nucleic acid was extracted by proteinase K phenol-chloroform standard method and then assessed by using beta-globin primer. Polymerase Chain Reaction [PCR] was then performed for papilomaviruses on all patients and positive cases from both types, including HPV 16 and 18 genotypes, were detected. Three hundred and eight women [15-75 years old] with mean age of 37.54 +/- 10.6 were recruited. Seventy six cases [20.1%] of whom were infected with HPV and 48.6% with HPV16 or 18 positive. Normal cytology was seen in 226 cases and 41 patients [18.1%] were HPV positive. Amongst those 152 cases with inflammation or abnormal cytology, 35 cases [23%] were HPV positive. No significant relation was reported between different variables and HPV infections. Due to high rate of HPV infection, as well as its high risk genotypes in different studies, more careful screening of women by Pap smear is recommended

Hydatidiform mole and surviving coexistent twin [a case report]

Hydatidiform mole with a coexistent fetus is a rare occurrence with an incidence of 1 per 22000-100000 pregnancies. It is associated with persistant gestational trophoblastic tumor. Hence an early and correct diagnosis is imperative to plan subsequent management of such patients. We report a case of primigravida who presented with vaginal bleeding and severe nausae and vomiting. Expectant management was carried out for her pregnancy with finally ended in abortion

[ assessment of urinary iodine and serum TSH concentration in pregnant women referred to Deziani Hospital in Gorgan - Iran [2004]]

No nutrient deficiency is as bad as iodine deficiency which attributed to a broad spectrum of disorders like goiter, abortion, hypothyroidism, etc. screening for hypothyroidism must be done before or just after pregnancy. The present study was conducted to evaluate serum TSH and urinary iodine concentration in pregnant women in Gorgan several years after salt iodization in Iran was implemented. From December to March 2004, 97 pregnant women referred for prenatal care to the Deziani Hospital of Gorgan were selected. 2 cc of blood for serum TSH measurement and 2cc of urine for iodine concentration measurement were collected. Urine iodine concentration was measured by acid digestion and TSH concentration was measured by ELISA method. 97 women, 86 [89%] women had normal urinary iodine, 11 women had iodine deficiency, 9 women had mild iodine deficiency [82%] and two women [18%] had moderate iodine deficiency none of them had severe iodine deficiency. Serum TSH was normal in 90 women and only in 7 women it was more than 4 and none of them had TSH less than 0.3. There were not any significant statistical correlation between age, weight, height, parity, goiter grading, salary, gestational age and urinary iodine concentration. According to low prevalence of iodine deficiency in this study iodine programs were successful in Gorgan and the mean urinary iodine is high so evaluating of iodine consumption for preventing of iodine overload is necessary. Because of complications of iodine deficiency especially in the first trimester of pregnancy regular measurement of urinary iodine must be done in reproductive ages before pregnancy or just after pregnancy