ABSTRACT
Introduction: Invasive breast cancer is the most common carcinoma in women. Immunohistochemistry classification now plays a key role in prognostic identification and prediction of outcome in this disease. Based on recent gene expression studies, immunohistochemical subtypes are as follows: Luminal A [ER+ and /or PR+, HER2-], luminal B [ER+ and /or PR+, HER2+], HER2+/ ER-, PR-, and basal-like [ER-, PR-, HER2-]. These molecular differences have been shown to correlate with clinical features, such as survival, and sensitivity to treatment. In this study we evaluated the association between different subtypes with histological type, grade, tumor stage, lymph node positive ratio, lymph node status, recurrence, and survival
Patients and methods: We retrieved the clinical records of 580 patients with breast cancer who were treated at Mahdieh Institute of oncology in Hamadan, Iran, between Oct 2004 and Oct 2011, and we evaluated clinicopathological data of these patients
Results: Mean age of patients was 47.22 +/- 11.1 years. Of 573 patients, 116 [20.2%] were ER /PR+, HER2+, 257 [44.9%] were ER /PR+, HER2-, 72 [12.6%] were ER /PR-, HER2+, 124 [21.6%] were ER /PR-, HER2- and 4 were undefined. The estimated median follow up period for all subjects was 4.9 years [range 3 months to 6.9 years]. The overall survival for all patients was 88.21% and the disease free survival was 83.7%. The interesting result of this study was the lower incidence of positive axillary lymph nodes in triple negative subtypes. Five-year relative survival rates were higher for patients with ER/PR+ and negative lymph nodes [p< 0.05]
Conclusion: This study highlighted the importance of immunohistochemical subtypes. As our patients were good representatives of breast cancer in western Iran and this study showed some differences with literature, further research should be directed at standardization of molecular and immunohistochemical methods in our country
ABSTRACT
Background: Solar lentigo is a dark brown macule. Its finding is relating to chronic solar exposure. It presents on exposing area [face and dorsal surface of hand]. Varient methods are used for treating solar lentigo for example cryotherapy. Cryotherapy is safe but there is on scientific study about suitable time for faster curative response. This research was done the objective of finding suitable time of cryotherapy for solar lentigo treatment without complication
Materials and Methods: This experimental study is a randomized clinical trial. 75 patients who had solar lentige [as the target group] were selected among patients that came to Department of Dermatology in sina hospital. They were studied of the basis of random allocation three groups. Each group contained 25 patients. These patients received cryotherapy in three varient time: [group A: 3-4 seconds, group B: 5-4 seconds, group B: 5-6 seconds and group V: 7-8 seconds]. Cryotherapy was done by liquid nitrogen and aplicator. Two weeks after giving cryotherapy, response treatment, complications and retreatment were evaluated. Collected date were analyzed by EP16 software and appropriate statistical methods
Results: Mean of treatment times in groups were: [group A: 4.44, group B: 3.28 and group C: 3.08]. In this study there was significant statistical difference among groups in solar lentigo treatment [P=0.0001]. In this study, serious complications from Cryotherapy weren't seen. In this study; Sex, age and location of lesion had no effect
Conclusions: Cryotherapy is recommended for solar lentigo treatment because not only it hasn't serious complications but also it is an easy method, and this study shows the most suitable time for faster and better reponse is 7-10 seconds
ABSTRACT
Background: Solar lentigo is a dark brown macule. Its finding is relating to chronic solar exposure. It presents on exposing area [face and dorsal surface of hand]. Varient methods are used for treating solar lentigo for example cryotherapy. Cryotherapy is safe but there is on scientific study about suitable time for faster curative response. This research was done the objective of finding suitable time of cryotherapy for solar lentigo treatment without complication
Materials and Methods: This experimental study is a randomized clinical trial. 75 patients who had solar lentige [as the target group] were selected among patients that came to Department of Dermatology in sina hospital. They were studied of the basis of random allocation three groups. Each group contained 25 patients. These patients received cryotherapy in three varient lime: [group A: 3-4 seconds, group B 5-4 seconds, group B: 5-6 seconds and group V: 7-8 seconds]. Cryotherapy was done by liquid nitrogen and aplicator. Two weeks after giving cryotherapy, response treatment, complications and retreatment were evaluated. Collected date were analyzed by EP16 software and appropriate statistical methods
Results: Mean of treatment times in groups were: [group A: 4.44, group B: 3 28 and group C: 3.08]. In this study there was significant statistical difference among groups in solar lentigo treatment [P=0.0001]. In this study, serious complications from Cryotherapy weren't seen In this study; Sex, age and location of lesion had no effect
Conclusions: Cryotherapy is recommended for solar lentigo treatment because not only it hasn't serious complications but also it is an easy method, and this study shows the most suitable time for faster and better response is 7-10 seconds