[ protective effects of Iranian golpar [Heracleum persicum] essential oil in liver damages induced by CCl4 in Wistar rats]

Background: Nowadays, liver disorders are one of the most serious and threatening problems of the health. Persian Golpar [Heracleum [H.] persicum] as an endemic medicinal plant with antioxidant and anti-inflammatory properties was used [noted] in the study for reducing the live injuries

Objective: This experiment -for the first time- was conducted to consider the effects of the oils obtained from fruits of Persian Golpar on the liver toxicity induced by the injection of tetrachloride carbon [CCl4] in the Wistar rats

Methods: In this study, 100 male Wistar rats were divided into 20 groups [n=5]. Negative control group [NC] received DMSO and olive oil for two weeks and the positive control group [C] received DMSO as i.p injection in 14 days following CCl4 [2 ml/kg b.w] at day 15th. The standard group [BHT], The treatment groups received H. persicum essential oils at both doses 100 and 200 mg/kg b.w as i.p injection following CCl4 [2 ml/kg b.w] at day 15th. Then, the levels of the glutathione [GSH], total antioxidant capacity of plasma [FRAP], proxidasion lipids [MDA] and glutathione stransferase [GST] and also liver enzymes for instance alanin teransferase [ALT] and aspartate teransferase [AST] were estimated at 4, 8, 16 and 24 h after CCL4 injection

Results: The injection of the essential oils [at the both doses] obtained from Persian Golpar could surprisingly modulate the changes of the antioxidant/oxidative parameters as well as liver enzymes induced by CCL4 administration

Conclusion: These results indicated the protective effect of Iranian Golpar essential oils on the liver. These effects are probably due to its antioxidant capacity

Evaluation the role of ferula gummosa essential oil against the hepatoxicity induced by acetaminophen in animal model

Background: Acetaminophen as a common antipyretic drug, in overdoses, is poisonous for the liver

Objective: The current study aimed to assess the protective effects of Ferula [F.] gummosa essential oils against the liver toxicity of acetaminophen in rats

Methods: 80 male Wistar rats were randomly divided into 16 groups [n=5]. Negative control group received only DMSO and the positive control group received acetaminophen 500 mg/kg b.w i.p. The treatment groups received F. gummosa essential oils [100 and 200 mg/kg b.w] i.p immediately after acetaminophen administration. The blood were collected for estimating the values of total antioxidant of plasma [FRAP] and liver enzymes; alanin teransferase [ALT], aspartate teransferase [AST], and alkaline phosphatase [ALP]. Also, a piece of liver was used for determining of glutathione [GSH], lipid peroxidation [LP] concentrations, the activity of glutathione s-transferase [GST] and histopathological studies

Results: The data showed that F. gummosa essential oil modulate significantly the changes in the levels of GSH, GST and FRAP as well as the liver enzymes and lipid peroxidation compared to negative control group. Furthermore, the histopathological findings of the liver tissue was confirmed the biochemical results

Conclusion: The essential oil extracted from F. gummosa possessed antioxidant activity which protects the liver against the toxic effects of acetaminophen