Synthesis and biological activity of some new 1,3,4oxidiazolo-1,3,4-thiadiazolo and 1,2,4-triazolothienophrrimidines

Reaction of hydrazones 2 in acetic acid and sodium acetate mixture gave oxadiazolotheinopyrimidines 3. Also, the acid hydrazides 1 reacted with carbon disulfide and potassium hydroxide gave oxadiazolothienopyrimidines of the type 4. Moreover, compounds 6 were heated either with 2N NaOH triazolopyrimidines 7 or with orthophosphoric acid gave thiadiazolothienopyrimidines 8. The structures of the final products were confirmed by spectral and microanalytical data. Some of the prepared compounds were tested against a variety of Gram- positive and Gram-negative strains of bacteria

Synthesis of phthalazine and 1,2,4-triazolo [4,3-b] -4,5benzo-pyridazine derivatives

Several derivatives of 1[2H] phthalazinones were reported to posses antibacterial, antitubercular and antifungal 930 activities. This prompted us to investigate the synthesis of some new phthalazinone and 1,2, 4-triazolo [4, 3-bl-4,5-benzopyridazine derivatives. The readily available o-[4-chloro-3-methyl] benzoylbenzoic acid[l] appeared to be a potential starting material for the synthesis of a number of interesting phthalazines

Synthesis of some new thienopyrimidines containing 4-thiazolidinons moiety

The reaction of 4-mercaptopyrimidines 1 with halogenated active methylene compounds in aqueous sodium carbonate gave compounds 2a-h. Compounds 2c,g were allowed to react with hydrazine hydrate in ethanol to give the acid hydrazides 4a,b. The latter was condensed with aromatic aldehydes and ketones to give the corresponding hydrazones 5. Cyclocondensation reaction of thioglycolic acid with hydrazones gave thiazolidinothienopyrimidines 6