effect of Sitagliptin [Januvia] on the liver of adult albino rats in cases of experimental diabetes mellitus[microscopic and laboratory studies]

The present study was carried out to evaluate the effect of Sitagliptin [Januvia] on the liver of experimentally induced diabetes in albino rats. Fifteen adult male albino rats were used and divided into three equal groups. The first group was considered as a control group. In the second group experimental induction of diabetes was performed by intraperitoneal injection of alloxan and left as a diabetic control for three weeks. The third group was consisted of rats of experimentally induced diabetes and treated by a daily dose of Sitagliptin [Januvia] as oral anti diabetic therapy for three weeks. Two main parameters were performed; the first was microscopic and histochemical studies on the liver tissue while the second was laboratory evaluation of some liver functions. The hepatic tissue was affected by the experimental induction of diabetes in the form of cellular infiltration, hepatic cell cords disarrangement and vascular congestion after three weeks of induction. The fibrous elements as well as mucopolysaccharides contents were greatly reduced. Histochemical changes in the liver enzymes showed mild decrease. Liver function tests showed mild changes. Diabetic changes were gradually returned back to its normal state after the use of daily oral dose of Sitagliptin. The antidiabetic drug [Sitagliptin] could be considered a good therapy in limiting the risk of diabetes Mellitus on liver tissue

Cholestasis in human fascioliasis in Dakahlia governorate, Egypt

This study was conducted to assess cholestasis in human fascioliasis. Twenty five patients, passing Fasciola eggs, were compared to twenty age- and sex-matched healthy controls. All were subjected to thorough clinical examination, stool analysis, complete blood picture, liver function tests [AST, ALT, SAP, GGT and total serum bilirubin]. Autoimmune and viral hepatitis [HCV and HBV] were excluded. All cases were subjected to radiological examinations [chest X-ray and abdominal ultrasonography]. The study revealed significant elevation of liver enzymes in the patients compared to the controls. Calcular and non-calcular cholecystitis were common findings among patients [32% and 24%, respectively]. Ascites [4%] and dilated intrahepatic biliary radicals [32%] were encountered; pleural effusion was detected by chest X-ray in 20% of cases. So, fascioliasis should be considered in the diagnosis of cholestasis in Fasciola endemic areas