ABSTRACT
Chronic Kidney disease [CKD] is characterized by impaired of innate and adaptive immunity. No studies have been conducted on disturbance of the immune system in Moroccans patients on hemodialysis. The aim of this study is to describe the cellular and humoral immune status in these patients. Fifty hemodialysis patients were recruited for this study. Lymphocyte subpopulations and assay of immunoglobulins and complement were determined for each patient. The analysis of the humoral response [dosage of IgGAM] showed increased levels of IgG, IgA and IgM in respectively 92, 28 and 2% of patients. Futher more a deficiency of IgM and IgA was found in 2 and 6% of patients respectively. Our results have shown high levels of C3 and C4 in 18 [36%] and 23 [46%] patients, respectively. Also a C3 deficiency in 3 patients [6%] and C4 in 5 patients [10%] was noted. Hemodialysis is accompanied by abnormalities of the innate and acquired immune system. Understanding the mechanisms underlying immune dysfunction on IRC, can improve lifestyle and reduce mortality in this group of patients. Several therapeutic strategies [targeted therapy] are being evaluated in order to avoid immune alterations in uremia