ABSTRACT
Tinea cruris is a relatively common fungal infection. For many years Griseofulvin has been considered as the treatment of choice and now, new oral antifungal agents including Fluconazol are being used widely. The aim of this study was comparison of therapeutic effects of Griseofulvin and Fluconazol for treatment of tinea cruris. This is a single blind clinical trial study on 64 patients with tinea cruris in Dermatology Department of Ghaem Hospital between August 2004 and February 2005. All patients had clinical exam and a positive KOH test for fungal infection at first, and four and seven weeks later. Patients divided into two groups randomly: 32 patients were treated with 150mg Fluconazol once weekly and 32 were treated with Griseofulvin 500mg daily. Our data were gathered by questionnaires and were analyzed by SPSS statistecally software. On the fourth week 60% of Fluconazol group and of Griseofulvin group had clinical improvement [p=0.2], laboratory mycological studies showed that 80% of Flouconazole group and%84.4 of Griseofulvin group have had improvement [p=0.4]. Patients who had positive fungal test in the fourth week were cured clinically and paraclinically in the seventh week. There weren't any statistically significant differences between two groups. Fluconazol as like as Griseofulvin is an effective therapy for tinea cruris and it was also a simple, inexpensive and safe treatment