ABSTRACT
Topical glycocorticoid therapy is the first choice for the treatment of eczema. Eczema is the most common inflammatory skin disease. Different degrees of itching is the outstanding feature of this disease. In this study we have tried to investigate the efficacy of herbal drug AJMT in comparison with fluocinolone acetonide on hand eczema. In this study 64 patients with hand eczema that referred to dermatology clinic, were randomly divided in two 32 patients group. One group was treated with topical fluocinolone actinide cream and the other with AJMT cream. After 2 weeks of treatment we analyzed the data with SPSS software, using Macnemar and X[2] tests. This study showed, there was significant statistical difference regarding to pruritus and erythema in pre and post therapy [P < 0.05]. The difference was not significant for other symptoms. The results of therapy in AJMT group is superior for symptoms of skin lichenification, scalliness and fissure compared to fluosinolone acetonide group. AJMT cream is more effective than fluosinolone acetonide in hand eczema. On the other hand due to more side effects with long usage of topical corticosteroids we prefer the AJMT cream for topical therapy on hand eczema