[Mycobacterium gordonae pulmonary infection with clinical manifestations similar to tuberculosis]

Background and Aim: Mycobacterium gordonae is one of the most important human mycobacterial pathogens that is found in immuno-compromised patients and also healthy people. This study is the first case report of Mycobacterium gordonae infection from Iran

Material and Methods: A 39-year-old woman with fever, weight loss, anorexia, chest pain and persistent cough referred to the emergency department of Al-Zahra Hospital in Isfahan,. A sputum sample was taken from the patient. After eleven days bacterial colonies were observed on the Lowenstein-Jensen Medium. Using microscopic evaluation and biochemical tests, the bacterial colonies were identified as Mycobacterium gordonae. Considering the antibiotic resistance pattern clarithromycin and levofloxacin, were prescribed for the patient. The patient's clinical signs were improved after 6 weeks

Conclusion: The clinical and radiological manifestations of mycobacterium gordonae and tuberculosis are similar and may be mistaken for each other. In addition, therapeutic regimen for non-tuberculosis mycobacteria and tuberculosis are different. Therefore it is necessary to identify mycobacteria to the species level

relationship of emotional responses and positive and negative symptoms with quality of life in schizophrenic patients

Schizophrenia is a chronic psychiatric disorder that were emotional responses and positive and negative symptoms role of playing in prognosis in schizophrenia. The studies results showed that emotional responses, positive and negative symptoms are important factors that impact quality of life in patients with schizophrenia. Determination the relationship of emotional responses, positive and negative symptoms with quality of life in schizophrenic patients.:This research was a descriptive correlation study. The Sample consisted of 100 patients with of schizophrenia who were selected among who were referred to Psychaitric Centers of Tehran. Collected with the Emotional Responses Scale, Positive and Negative Symptoms Scale and Quality of Life Scale were use. Data was analyzed using Pearson correlation coefficient and multiple regression analyses. The results of pearson correlation coefficients showed that positive emotional responses [r=0.02] positive symptoms [r=-0/04] and negative symptoms [r=-0.042] and related to are quality of life in schizophrenia patients [P <0.001]. The results of multiple regression showed that negative symptoms, had significant contribute in prediction of quality of life in schizophrenia patients. The results are in keeping with findings from other studies, the results indicated that role of positive emotional responses and positive and negative symptoms in quality of life of schizophrenia patients

[Genetic analysis of FMF in a small village with high frequency in North West of Iran]

Familial Mediterranean Fever [FMF] is an inherited inflammatory disorder which caused by mutations in the MEFV gene. The disease is common among Turks, Armenians and Arabs, whereas no data from the neighbor countries is available. We studied an 8 years old boy with periodic fever and recurrent abdominal pain. Genotype analysis was performed by reverse-hybridization for 12 most frequent variants. Result indicated the patient and several individuals in the family were compound heterozygote or homozygote for the mutations. Genetic analysis for the other individuals without any clinical features in the village showed an allelic frequently of 22%, which is the highest rate reported to date

[Genetic analysis for Gaucher disease in two Iranian families]

Gaucher disease [GD] is one of the lysosomal storage disorders which inherited in an autosomal recessive mode. There is no data available from the incidence of the disease in Iran. The aim of the study was to determine the type of mutations and clinical information in Iranian patients. After detection of the mutations for the parents we performed prenatal diagnosis for the pregnancies at risk. The result of genetic analysis for two families was similar and indicated L444P mutation for both diagnoses. The result indicated that the two fetuses were normal for the disease and inherited L444P mutation in heterozygote status