ABSTRACT
50 patients with hyper-thyroidism [25 with Graves' disease and 25 with toxic nodulas goiter] and 25 normal volunteers were included in this study. Thyroglobulin and microsomal antibodies were present in thyrotoxic patients of both groups with non significant differences. The frequency of presence of thyroglobulin and microsomal antibodies in the groups: total thyrotoxic patients, Graves' disease, toxic nodular goiter and in normal controls were as follows: Thyroglobulin antibody: 60%, 56%, 64% and 4% respectively. Microsomal antibody: 72%, 64%, 80% and 8% respectively. After medical control: We had variable results: In Graves' disease: as regards thyroglobulin antibody: 11 patients with positive thyroglobulin antibody titers: 8 show decrease in titer and 3 show increase titer. As regards microsomal antibody: 12 patients with positive microsomal antibody titers; 7 show decrease in titer and 5 show increase titer. In toxic nodular goiter: As regard thyroglobulin antibody: 11 patients with positive thyroglobulin antibody titers; 6 show decrease; 1 increase and 4 had no change in titers. As regards microsomal antibody: 14 patients with positive microsomal antibody titers; 6 decrease, 5 increase and 3 had no change in titer. All patients with undetectable thyroglobulin or microsomal antibodies [negative cases] remained negative with medical control. Our study shows no correlation between either T3 levels or T4 levels and positive microsomal and thyroglobulin antibody titers before treatment. Our results of the proportion of total T-lymphocytes in patients with toxic nodular goiter, Graves' disease and normal subjects, show no significant differences between both group of patients and normal subjects. There is no significant difference in T-lymphocytes in group of patients before and after medical control. Our study also shows no correlation between the proportion of total T-lymphocyte cells and thryroid hormones [T3 and T4]