ABSTRACT
ABSTRACT @#Restorative treatment is very challenging for non-carious cervical lesions (NCCLs) due to functional and structural complexities. The purpose of this randomised controlled trial (RCT) was to evaluate the clinical performance of nanocomposite restorations bonded using universal adhesive in self-etch mode with and without air abrasive surface treatment for NCCLs. A total of 70 NCCLs, from a group of consenting patients who fulfilled the inclusion criteria, were recruited for the study. The study was carried out following CONSORT guidelines. Block randomisation was done for equal allocation of lesions into; Group 1 (surface treatment with alumina air abrasion) and Group 2 (control group without mechanical surface treatment). The lesions were restored with nanocomposite using a universal bonding agent in self-etch mode. The clinical performance of the restorations was evaluated by two examiners using modified United States Public Health Service (USPHS) criteria at baseline, 3 months, 6 months and 12 months. A Chi-square test was performed for inter-group comparison. Cochran’s Q test and Dunn’s post hoc analysis were used for intra-group comparison. The inter-group comparison revealed no statistically significant difference between the experimental and control group for all the parameters assessed. With the intra-group analysis, it was found that there was a significant decrease in the performance of the restorations concerning marginal staining, marginal adaptation and surface texture during the evaluation period (p < 0.05). However, all of them demonstrated clinically acceptable performance. According to the results of this RCT, it was concluded that airborne particle abrasion of NCCLs did not improve the clinical performance of nanocomposite resin bonded using universal adhesive.
Subject(s)
Composite Resins , Air Abrasion, DentalABSTRACT
Background@#Asbestos exposure is associated with the development of the cancer malignant mesothelioma (MM). Measurement of soluble mesothelin-related protein (SMRP) has been suggested as a method for detection of MM in its early stages. We prospectively examined SMRP levels in participants with asbestos exposure who are a group at a high risk of development of MM. @*Methods@#This study was a follow-up of our cohort of 322 asbestos-exposed participants. No further participants developed MM or malignancy over the study period. Mean follow-up time was 22.9 months. @*Results@#Mean (standard deviation) SMRP levels at baseline and follow-up were 0.94 (0.79) and 0.91 (0.86) nmol/L (p = 0.1033), respectively. Mean SMRP levels of the healthy individuals exposed to asbestos at baseline was significantly lower than those of participants with asbestosis and pleural plaques alone; similar patterns were found on follow-up measurements. There was a statistically significant effect of age on serial SMRP measurements. Our study confirms higher levels in participants with nonmalignant asbestos-related disorders. Levels decreased in asbestos-related disorders other than asbestosis, where a small increase was observed. We did not detect any further cases of malignancy. @*Conclusion@#Monitoring programs for early detection of MM need to take into account increased SMRP levels found in benign asbestos-related diseases.
ABSTRACT
Background@#Asbestos exposure is associated with the development of the cancer malignant mesothelioma (MM). Measurement of soluble mesothelin-related protein (SMRP) has been suggested as a method for detection of MM in its early stages. We prospectively examined SMRP levels in participants with asbestos exposure who are a group at a high risk of development of MM. @*Methods@#This study was a follow-up of our cohort of 322 asbestos-exposed participants. No further participants developed MM or malignancy over the study period. Mean follow-up time was 22.9 months. @*Results@#Mean (standard deviation) SMRP levels at baseline and follow-up were 0.94 (0.79) and 0.91 (0.86) nmol/L (p = 0.1033), respectively. Mean SMRP levels of the healthy individuals exposed to asbestos at baseline was significantly lower than those of participants with asbestosis and pleural plaques alone; similar patterns were found on follow-up measurements. There was a statistically significant effect of age on serial SMRP measurements. Our study confirms higher levels in participants with nonmalignant asbestos-related disorders. Levels decreased in asbestos-related disorders other than asbestosis, where a small increase was observed. We did not detect any further cases of malignancy. @*Conclusion@#Monitoring programs for early detection of MM need to take into account increased SMRP levels found in benign asbestos-related diseases.
ABSTRACT
Bruxismo se define como un trastorno del movimiento mandibular que se caracteriza por apretamiento o rechinamiento dentario. Se estima que la prevalencia de éste puede variar desde un 8 por ciento a un 20 por ciento de la población adulta. Quienes padecen esta parafunción relatan manifestación en otras personas del grupo familiar. Existen teorías que buscan explicar la etiología del bruxismo, basados principalmente en estudios clínicos y encuestas a pacientes. Estas proponen que los principales factores etiológicos de Bruxismo serían estrés y alteraciones en ciertos neurotransmisores o sus vías (Dopamina, Ácido Gamma-Aminobutírico y Serotonina). La posibilidad de que alteraciones genéticas del ADN influyan en la aparición de bruxismo no ha sido considerada. Dado que no existe en la literatura consultada estudios genético-moleculares y/o funcionales que confirmen las teorías basadas en estudios clínicos, parece necesario iniciar investigaciones en esta área que lleven a una mejor comprensión de esta parafunción, con el ánimo final de aportar en el desarrollo de más y mejores terapias para el tratamiento del bruxismo...
Bruxism has been defined as a sleep-related movement disorder characterized by tooth grinding or clenching. Between 8 percent to 20 percent of adult population is affected by this parafunction. Relatives of these patients have reported to be affected by bruxism as well. There are theories that want to explain bruxism ethiology based on factors as stress and alteration in neurotransmitters (Dopamine, GABA and Serotonin). Possible epigenetic alterations in DNA influencing bruxism appearance have not been considered. It is therefore necessary to perform genetic, epigenetic and molecular research to confirm theories related to bruxism ethiology, with the aim to improve knowledge in this field as well as to contribute in the development of new and better therapies in bruxism treatment...
Subject(s)
Humans , Bruxism/genetics , Dopamine , gamma-Aminobutyric Acid , Serotonin , Bruxism/classification , Bruxism/physiopathology , Epigenesis, GeneticABSTRACT
OBJECTIVES: Asbestos-related diseases (ARDs) have increased globally over the decades, causing an economic burden and increased health care costs. It is difficult to predict the risk of development of ARDs and of respiratory disability among workers with a history of asbestos exposure. Blood based biomarkers have been reported as promising tools for the early detection of malignant mesothelioma. This study investigated whether serum soluble mesothelin-related peptide (SMRP) would reflect severity of disablement in compensable ARDs. METHODS: SMRP levels were measured in a cohort of 514 asbestos-exposed subjects. Severity of ARDs was assessed by a Medical Authority comprising four specially qualified respiratory physicians. Severity of ARDs and SMRP levels were compared. RESULTS: Mean (standard deviation) serum SMRP level in the population with compensable ARDs (n = 150) was 0.95 (0.65) nmol/L, and was positively associated with disability assessment (p = 0.01). Mean SMRP level in healthy asbestos-exposed subjects was significantly lower than those with pleural plaques (p < 0.0001) and in subjects with ARDs who received compensation (p < 0.01). CONCLUSION: This study indicates that serum SMRP levels correlate with severity of compensable ARDs. Serum SMRP could potentially be applied to monitor progress of ARDs. Further prospective work is needed to confirm the relationship between SMRP and disability assessment in this population.
Subject(s)
Asbestos , Biomarkers , Cohort Studies , Compensation and Redress , Health Care Costs , Mesothelioma , Organothiophosphorus CompoundsSubject(s)
Humans , Female , Gingival Recession , Dental Prosthesis , Gingival Diseases , PeriodontitisABSTRACT
Human epidermal growth factor receptor-2[HER2] over expression in invasive breast cancer is associated with a faster rate of tumour growth and poor prognosis. We aimed to evaluate the frequency of positive HER2 receptors in our patients and its impact on prognosis. Fifteen patients diagnosed to have invasive breast cancer were randomly chosen from patients that were treated in the department of oncology, Royal Hospital from 1991 to 2000. The expression of HER2/neu status was examined by using immunohistochemical-staining methods [Hercep test]. Between the HER2-positive and HER2-negative patients, the disease free period [DFP] and overall survival [OS] were compared. Thirteen of the studied 15 patients were females [87%] and 2 patients were males [13%]. An over expression of HER2/neu receptor protein occurred in 8 patients [53%]. There was no significant difference in term of prognostic factors between HER2-positive and HER2-negative patients. The DFP for patients who had HER2-positive receptors was was 42 months versus 10 months for patients with negative HER2 receptors [p=0.0530]. the OS for HER2 positive and negative receptors was 69 months and 15 months respectively [p=0.008]. High incidence of HER2 positive receptors was found among studied Omani patients. Breast cancer over expressing HER2/neu protein tends to have a poor prognosis with short DFP and OS
Subject(s)
Humans , Male , Female , Receptor, ErbB-2 , Prognosis , Proto-Oncogene ProteinsABSTRACT
Se presenta una serie clíniva de 4 lesiones traumáticas altas consecutivas de arteria humeral. Cada lesión fue diferente en su presentación y manejo. Un caso se resolvió con trombólisis luego de 24 h de isquemia y los otros 3 con cirugía. Dos casos terminaron en amputación, ambos infectados: uno con bypass permeable y el otro con trombosis tardía de un reimplante de extremidad. El último caso resolvió exitosamente con cirugía