ABSTRACT
To study the disease pattern and treatment response of Hodgkin's Disease in our patients. Prospective study from Jan 1995 to June 1997. Armed Forces Institute of Pathology and Oncology Department of CMH, Rawalpindi. Patients with newly diagnosed Hodgkin's Disease. Disease pattern on presentation and response to various therapeutic protocols. Thirty patients were included in the study, 19 males and 11 females. Age of patients ranged from 3.5-90 years with a median of 32.5 years. Histologically mixed cellularity was the most common subtype [76.6%]. Most of the patients had advanced disease, 46.6% stage III and 16.6% were in stage IV at the time of initial presentation. Overall Complete Remission [CR] rate was 82%. There was no significant difference between the CR rate among the patients who received ABVD [10 out of 12 achieved CR] and MOPP variants [9 out of 12 achieved CR]. Complete response rate is 82% which is similar to the other centres of the world. Results of treatment with ChlVPP, C-MOPP and LOPP are almost equal to ABVD. These modifications of MOPP are very cheap as compared to ABVD, ChlVPP is almost ten times cheaper. These regimens can be safely recommended without compromising treatment benefits. This observation is very pertinent in developing countries like Pakistan, where resources allocated for health facilities are very limited