[Antibiotic-resistance patterns of helicobacter pylori isolates obtained from patients in Kerman- 2009]

Background and Aims: Based on serological studies the prevalence of Helicobacter Pylori infection in Iranian adults is up to 80%. Gastritis, peptic ulcer and gastric adenocarcinoma are common clinical outcomes of this infection in Iran. Since antibiotic resistance patterns of Helicobacter pylori are different geographically, local studies are highly required

Method: From April to December 2009, 63 isolates of Helicobacter pylori were obtained From 191 patients referred to the endoscopy unit of Afzalipour hospital in Kerman. Demographic features including age, gender, symptoms, were recorded before the sampling and sensitivity to six common antibiotics used for the treatment of H.pylori infection was determined. Modified disk diffusion test was used to evaluate antibiotic resistance pattern. Data analysis was done through SPSS 16 and using Pearson chi-square test

Results: The patterns of antibiotics resistance were as below: metronidazole 55.5%, clarithromycin 30.1%, tetracycline 3.1%, amoxicillin 26.9%, ciprofloxacin 7.9% and no resistance to furazolidone was detected. While 12.7% of the isolates were susceptible to all the six antibiotics, 55.6% were resistant to one antibiotic, 25.4% to two antibiotics, 6.3% to three antibiotics and there was no resistance to more than three antibiotics at the same time

Conclusion: According to the obtained antibiotic resistance rates in this study, performing antibiogram tests before starting the treatment is necessary

[Demographic and clinical features of ulcerative colitis patients in Kerman city during 2005-2007]

Ulcerative colitis is one of the inflammatory bowel diseases with unknown etiology. Genetic and environmental factors are thought to be effective in this disease. According to the limited studies in our country, general assessment of demographic features and clinical symptoms seems to be essential. In this prospective and cross-sectional study, 85 cases of ulcerative colitis referred to the 3 gastroenterologist offices in Kerman city were evaluated during 2005-2007. The diagnosis was confirmed based on clinical features, colonoscopy, pathology and ruling out of other causes. Data were collected through direct interview and analyzed by SPSS 15 software. Mean age at the time of diagnosis was 33.31 +/- 13.12. Duration of symptoms onset until diagnosis was 8 months. Male to female ratio was 0.8/1 and the most important clinical manifestations were rectorhagia and bloody diarrhea [92.9%], abdominal pain [20%], mucoid diarrhea [13.1%], weight loss [11.2%] and fever [4.4%]. The pattern of disease was chronic intermittent in 83.5%, chronic continuous in 13% and acute self-limited in 3.5%. Anatomically disease was limited to the rectum [8.3%], recto sigmoid [23.5%], recto sigmoid and descending colon [28.5%], transverse colon [21.2%] and pan colitis. [18.8%]. Extra intestinal manifestations were seen in 22.35% of cases of whom 12.96% had oral involvement, 5.85% had hepatic involvement and 3.53% had musculoskeletal involvement. Recurrent inflammatory bowel disease is one of the important reasons of referral to gastroenterologists. Ulcerative coilitis in Kerman is similar to other countries of world epidemiologically, demographically and clinically but its seems that severe clinical courses, extra intestinal manifestations and second old age peak to be less comparing to other studies

[Pancreatobiliary cancers in Iran: a population- based study]

Our knowledge regarding the epidemiology of pancreatobiliary cancers in Iran is limited. This study presents the first population-based report on pancreatobiliary cancers performed in five provinces of Iran. Data used in this study were retrieved from population-based cancer registries in five provinces of Iran [Gilan, Mazandaran, Golestan, Ardabil and Kerman] from 1996 to 2000. Crude incidence rate, age standardized incidence rate [ASR] and age specific incidence rate were calculated for each cancer sites using the direct method. Overall ASR of pancreatic cancer in five provinces was 1.18 and 0.84 per 100, 000 person-years for men and women, respectively. These values for gallbladder and biliary tract cancers were 0.42 and 0.27 per 100, 000 person-years for men and 0.93 and 0.22 per 100, 000 person-years for women, respectively. ASR of pancreatobiliary cancer is low in Iran compared to western countries

first population-based Cancer survey in Kerman province of Iran

Cancer is the second most common cause of non-accidental death in Iran. Geographical, racial and habitual differences have led to the variation in the incidence of cancer in different regions of this country. This study was performed to determine the incidence of cancer in the Kerman Province, central Iran. All newly diagnosed cases of cancer in the Kerman Province were recorded in a five-year period [1996-2000]. In all, 5884 new cases [55.7% males] of cancer were found after elimination of repeated cases. Based on age-standardized incidence rates [ASR] the most common cancers in men were stomach [10.2], lung [7.1], bladder [6.7], colorectal [5.9] and non-Hodgkin's lymphoma [5.8], while in women the most common cancers were breast [16.9] colorectal [5.9], stomach [5.1], leukaemia [4.6] and non-Hodgkin's lymphoma [2.8]. For all cancers, ASR was 76 for males and 68 for females. The results indicate that upper gastrointestinal cancer, especially oesophageal cancer is very rare in central Iran in contrast to northern Iran, although these types of cancers are some of the most common cancers in the Kerman Province

[ incidence rate of gastrointestinal tract cancers in Kerman province during 1996-2000]

Cancer as the second leading cause of death following cardiovascular diseases has always been a threat to human life and due to its peculiar nature and lack of a favorable treatment, it is considered as a research priority in all communities. Understanding the geographical distribution of the incidence of various tumors, constitutes the first step in health and treatment planning. This study was carried out to review the incidence rate of gastrointestinal cancers in Kerman province and estimate disease load in this geographical area. Through a community-based registration system, all the documents related to cancer diagnosis in Kerman province from 1996 to 2000 were investigated. Among 5867 registered cases of cancer with an average age of 51.5 +/- 20.6 years, men composed 55.5% and women 44.5% of the cases and 1303 ones [22.2%] had gastrointestinal tract cancers among them gastric tumors [39%] had the highest incidence rate. Following gastric tumors, tumors of colon [29.4%], esophagus [12.5%], liver [5.83%] gallbladder [5.3%], and pancreas [2.84%] acquired the next ranks in regard to the incidence rate. The incidence pattern of aforementioned cancers in men showed the same pattern as the general population, but in women, colon tumors with the incidence rate of 35% have the highest incidence rate while tumors of the stomach [29.71%], esophagus [10.15%], gallbladder [9.8%], liver [5.26%] and pancreas [4.32%] were the next. Although, various GI malignancies have a lower incidence rate in Kerman province compared with other countries, the fact that these malignancies account for 22.4% of all malignancies, greatly enhances the need for serious planning for prevention, early diagnosis and correction of improper dietary habbits in this province. Moreover development of a versatile cancer registration system to evaluate the domestic comparisons seems essential