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Egyptian Journal of Pharmaceutical Sciences. 1991; 32 (3-4): 601-612
in English | IMEMR | ID: emr-19755

ABSTRACT

A simple volumetric method for the determination of each of piroxicam and diclofenac sodium is suggested based on the reaction with N- bromosuccinimide [NBS]. The direct titration with NBS is only successful for piroxicam in glacial acetic acid medium using methyl orange as indicator. However, the indirect titration is described for both piroxicam and diclofenac sodium, in which the drug solution is allowed to react with a known excess of standard NBS solution for the specified time and the excess NBS is back titrated iodometrically. The different factors affecting the titrations are discussed. The method determines 1.2 mg of piroxicam in the direct titration with a mean accuracy of 100.4 +/- 1.03% and determines 2-12 mg of piroxicam and 1-15 mg of diclofenac sodium in the indirect titration with mean accuracies of 100.0 +/- 0.53% and 100.1 +/- 0.78%, respectively


Subject(s)
Piroxicam , Pharmacokinetics , Bromosuccinimide
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