Synthesis of some new fluorene-amino acid derivatives of expected biological activity

The synthesis of fluorenone [and 7-nitrofluorenone]-4-carboxamido acids [3a-4e], their methyl esters [5a-6e] and their corresponding hydrazino hydrazide derivatives [7a-8e] was described. In addition, some dipeptide analogues in the form of their methyl esters [9a-10c] and hydrazides [11a-12c] were synthesized. Most of the synthesized nitro derivatives were found to possess an interesting antimicrobial activities against number of microorganisms