ABSTRACT
The aim of the present study was to compare the effectiveness of intrauterine [IUI] versus direct intraperitoneal insemination [DIPI] in treatment of cases of unexplained of infertility. This study was carried out on 60 couples during their reproductive period complaining of primary unexplained inferitility. The selected cases were randomly divided into two groups, thirty patients each. Women of first group were submitted to IUI and those of the second group were submitted to DIPI. Controlled induction of ovulation was performed by clompihene citrate [CC] given in a dose of 50 mg twice daily for five days starting from the 3rd day of menstrual cycle. Ultrasonographic monitoring of ovulation started from the 10th day of the cycle to determine the size of Graffian follicle. The female was injected with 10000 I.U. of hCG once the ovum reached the size of 17-18 mm. in diameter. Insemination was carried out twice, 24 and 48 hours after hCG injection using husband's semen after washing and swim up of the sperms. In the present study, the cumulative pregnancy rate with IUI was 16.67%; while that of the DIPI was 3.30% that was significantly lower than that of IUI. From the present study, one concluded that both IUI and DIPI plus induction of ovulation by CC/hCG are valuable methods for treatment of unexplained infertility. However, IUI is more effective and more physiological than DIPI. The latter approach should be practiced only when IUI would be difficult or failed