ABSTRACT
Transitional cell carcinoma of renal pelvis presenting with brain metastases is a very rare case which should be diagnosed and treated in order to prevent further damages. We report a rare case, who had presented with a constellation of neurological symptoms [due to multiple brain metastases], but without any urological symptoms. During evaluation of patient, we found transitional cell carcinoma [TCC] of left renal pelvis, for which palliative radical nephroureterectomy was performed. Although transitional cell carcinoma of renal pelvis presenting with brain metastases is a very rare case, but the patient was managed with gamma knife stereotactic radiosurgery for the metastatic lesions. Afterward he received four cycles of paclitaxel and carboplatin chemotherapy. The patient is alive with stable disease at 32-months' follow-up