ABSTRACT
Thalassemia is a type of genetic disease that is classified in the group of heritable anemia. Due to anemia hemoglobin level decreases and blood transfusion is used to composed that finally results in excessive iron content. In order to eliminate the excessive iron, Desfral is prescribed. The excessive iron creates undesirable complications on liver, heart and endocrine glands tissues. The most important complication in the patients suffering from thalassemia is restrictive cardiomyopathy and rhythm disorders and cardiac blockage insufficiency. Determination of the effect of aerobic rehabilitation program on density of Ferritin, Iron, TIBC and cardiovascular operation in the young adult patients with major thalassemia. This research performed in semi experimental method on 15 patients 10 to 16 yearsold suffering from thalassemia with history of 9 to 15 years were studied in a 50- individual population. Research process for these patients was performed in three sections of pretest, during test and posttest. Research data were analyzed with correlation method and X[2] test. Average blood ferritin after first sport test and an eight-week aerobic program was decreased considerably as compared with rest [P<0.05] and blood iron after sport test and after aerobic practices as compared with rest time showed significant decreased [P<0.05]. In heart beat frequency domain in the duration of rest after aerobic practices, progressive decrease was observed [P<0.05]. The effective aerobic rehabilitation program in patients with major thalasemia should be managed based on medical examination and balk sport test. Despite of the creasing aeron and ferritin load, it can cause a freshness mentality during blood transfusion and desferal administration physical practices in the safe physiologic domain, the harmful effect of excessive iron on heart decreases and therefore their cardiovascular operation improves